Sohlh2 - spermatogenesis and oogenesis specific basic helix-loop-helix 2 Gene

Mus musculus

Also known as Sosf2; 4933406N12Rik

Gene ID: 74434 | Gene type: protein coding

About Sohlh2

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in oocyte differentiation; positive regulation of transcription by RNA polymerase II; and spermatogenesis. Acts upstream of or within primary ovarian follicle growth and regulation of gene expression. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in early conceptus; eye; genitourinary system; heart; and liver. Orthologous to several human genes including CCDC169-SOHLH2 (CCDC169-SOHLH2 readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Sohlh2 Products(1)

mRNA	Protein	Name
NM_028937.3	NP_083213.2	spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22328502	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22328502	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	22056784	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22056784	MGI
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	22056784	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	22056784	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell differentiation	IDA IDA: Inferred from direct assay	22056784	MGI
involved in oocyte differentiation	IDA IDA: Inferred from direct assay	28504655	MGI
acts upstream of or within oocyte differentiation	IMP IMP: Inferred from mutant phenotype	18753606	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22328502	MGI
acts upstream of or within primary ovarian follicle growth	IMP IMP: Inferred from mutant phenotype	18753606	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18753606	MGI
involved in spermatogenesis	IDA IDA: Inferred from direct assay	22056784	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13565	SOHLH2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sohlh2	NCBI	NCBI:54937

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