Sohlh2 - spermatogenesis and oogenesis specific basic helix-loop-helix 2 Gene

Also Known as Sosf2; 4933406N12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74434

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in oocyte differentiation; positive regulation of transcription by RNA polymerase II; and spermatogenesis. Acts upstream of or within primary ovarian follicle growth and regulation of gene expression. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in early conceptus; eye; genitourinary system; heart; and liver. Orthologous to several human genes including CCDC169-SOHLH2 (CCDC169-SOHLH2 readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Sohlh2 Products (1)

mRNA Protein Name
NM_028937.3 NP_083213.2 spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
22328502 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
22328502 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
22056784 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22056784 MGI
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
22056784 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
22056784 MGI
Biological Process GO Annotation Evidence References Source
involved in cell differentiation IDA
IDA: Inferred from direct assay
22056784 MGI
involved in oocyte differentiation IDA
IDA: Inferred from direct assay
28504655 MGI
acts upstream of or within oocyte differentiation IMP
IMP: Inferred from mutant phenotype
18753606 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22328502 MGI
acts upstream of or within primary ovarian follicle growth IMP
IMP: Inferred from mutant phenotype
18753606 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18753606 MGI
involved in spermatogenesis IDA
IDA: Inferred from direct assay
22056784 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13565 SOHLH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sohlh2 NCBI NCBI:54937