Abca12 - ATP-binding cassette, sub-family A (ABC1), member 12 Gene

Predicted to enable ATPase-coupled transmembrane transporter activity; Apolipoprotein A-I receptor binding activity; and lipid transporter activity. Involved in several processes, including corneocyte desquamation; positive regulation of intracellular lipid transport; and regulation of Insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within several processes, including positive regulation of Cholesterol efflux; positive regulation of protein localization to cell surface; and skin development. Located in cytosol. Is expressed in adrenal gland; epidermis; and gland. Used to study autosomal recessive congenital ichthyosis 4B. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1; autosomal recessive congenital ichthyosis 4A; and autosomal recessive congenital ichthyosis 4B. Orthologous to human ABCA12 (ATP binding cassette subfamily A member 12). [provided by Alliance of Genome Resources, Apr 2022]