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Selenon - selenoprotein N Gene

Also Known as SelN; Sepn1; 1110019I12Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 74777

Summary

This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in the orthologous gene in human are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. Knockout mice deleted for this gene exhibit abnormal lung development. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. [provided by RefSeq, Dec 2016]

Selenon Products (1)

mRNA	Protein	Name
NM_029100.2	NP_083376.2	selenoprotein N precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within ATP metabolic process	IMP IMP: Inferred from mutant phenotype	32661288	MGI
acts upstream of or within L-ascorbic acid metabolic process	IMP IMP: Inferred from mutant phenotype	28106121	MGI
acts upstream of or within L-ascorbic acid transmembrane transport	IMP IMP: Inferred from mutant phenotype	28106121	MGI
acts upstream of or within calcium ion transport	IMP IMP: Inferred from mutant phenotype	32661288	MGI
acts upstream of or within cellular response to caffeine	IMP IMP: Inferred from mutant phenotype	23325319	MGI
acts upstream of or within cellular response to oxidative stress	IGI IGI: Inferred from genetic interaction	25452428	MGI
acts upstream of or within cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	23325319	MGI
acts upstream of or within collagen fibril organization	IMP IMP: Inferred from mutant phenotype	28106121	MGI
acts upstream of or within energy reserve metabolic process	IMP IMP: Inferred from mutant phenotype	32661288	MGI
acts upstream of or within generation of precursor metabolites and energy	IMP IMP: Inferred from mutant phenotype	32661288	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	23325319	MGI
acts upstream of or within membrane biogenesis	IMP IMP: Inferred from mutant phenotype	32661288	MGI
acts upstream of or within membrane organization	IMP IMP: Inferred from mutant phenotype	32661288	MGI
acts upstream of or within membrane to membrane docking	IMP IMP: Inferred from mutant phenotype	32661288	MGI
acts upstream of or within mitochondrial calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	32661288	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	23325319	MGI
acts upstream of or within mitochondrion-endoplasmic reticulum membrane tethering	IMP IMP: Inferred from mutant phenotype	32661288	MGI
acts upstream of or within multicellular organismal response to stress	IMP IMP: Inferred from mutant phenotype	21858002	MGI
acts upstream of or within muscle structure development	IMP IMP: Inferred from mutant phenotype	32661288	MGI
acts upstream of or within positive regulation of skeletal muscle cell proliferation	IDA IDA: Inferred from direct assay	21131290	MGI
acts upstream of or within respiratory system process	IMP IMP: Inferred from mutant phenotype	23325319	MGI
acts upstream of or within response to muscle activity involved in regulation of muscle adaptation	IMP IMP: Inferred from mutant phenotype	23325319	MGI
acts upstream of or within skeletal muscle fiber development	IMP IMP: Inferred from mutant phenotype	23325319	MGI
acts upstream of or within skeletal muscle satellite cell differentiation	IMP IMP: Inferred from mutant phenotype	21131290	MGI
involved in skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	IMP IMP: Inferred from mutant phenotype	21131290	MGI
acts upstream of or within skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	28106121	MGI
acts upstream of or within skeletal muscle tissue regeneration	IMP IMP: Inferred from mutant phenotype	21131290	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28106121	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	28106121	MGI
is active in mitochondria-associated endoplasmic reticulum membrane contact site	IMP IMP: Inferred from mutant phenotype	32661288	MGI
is active in mitochondrial membrane	IDA IDA: Inferred from direct assay	32661288	MGI
is active in mitochondrion	IMP IMP: Inferred from mutant phenotype	32661288	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
selenoprotein N	selenoprotein N, 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12639	SELENON Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Selenon	NCBI	NCBI:57190