Asxl2 - ASXL transcriptional regulator 2 Gene

Also Known as mKIAA1685; 4930556B16Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 75302

Summary

This gene encodes a homolog of the Drosophila Asx gene, which interacts with genes involved in axial patterning. Mice with mutations in this gene display abnormal patterning of the axial skeleton, suggesting a similar function in mice as in Drosophila. This gene may also be involved in bone mineral density, specifically osteoclastogenesis. [provided by RefSeq, Aug 2012]

Asxl2 Products (4)

mRNA	Protein	Name
NM_001270988.2	NP_001257917.1	putative Polycomb group protein ASXL2 isoform 1
NM_172421.6	NP_766009.2	putative Polycomb group protein ASXL2 isoform 2
NM_001270988.2	NP_001257917.1	putative Polycomb group protein ASXL2 isoform 1
NM_172421.6	NP_766009.2	putative Polycomb group protein ASXL2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	23046516	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22878500	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adult heart development	IMP IMP: Inferred from mutant phenotype	23046516	MGI
acts upstream of bone mineralization involved in bone maturation	IMP IMP: Inferred from mutant phenotype	21490954	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	19270745	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	19270745	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	24860998	MGI
acts upstream of macrophage differentiation	IMP IMP: Inferred from mutant phenotype	21490954	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23046516	MGI
acts upstream of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	21490954	MGI
acts upstream of or within positive regulation of bone mineralization involved in bone maturation	IMP IMP: Inferred from mutant phenotype	21490954	MGI
acts upstream of or within positive regulation of macrophage differentiation	IMP IMP: Inferred from mutant phenotype	21490954	MGI
acts upstream of or within positive regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	21490954	MGI
acts upstream of or within positive regulation of transferase activity	IMP IMP: Inferred from mutant phenotype	19270745	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	20577743	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
putative Polycomb group protein ASXL2	additional sex combs like 2, transcriptional regulator additional sex combs-like protein 2 polycomb group protein ASXH2 homolog

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01115	ASXL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Asxl2	NCBI	NCBI:55252