Secisbp2 - SECIS binding protein 2 Gene

Also Known as SBP2; 2210413N07Rik; 2810012K13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 75420

Summary

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in a similar gene in human have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

Secisbp2 Products (2)

mRNA Protein Name
NM_001308448.1 NP_001295377.1 selenocysteine insertion sequence-binding protein 2 isoform 2
NM_029279.2 NP_083555.1 selenocysteine insertion sequence-binding protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22992746 MGI
enables ribonucleoprotein complex binding IDA
IDA: Inferred from direct assay
22992746 MGI
enables selenocysteine insertion sequence binding IDA
IDA: Inferred from direct assay
22992746 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within RNA catabolic process IMP
IMP: Inferred from mutant phenotype
27956496 MGI
acts upstream of or within forebrain neuron development IMP
IMP: Inferred from mutant phenotype
24844465 MGI
acts upstream of or within mRNA stabilization IMP
IMP: Inferred from mutant phenotype
27956496 MGI
acts upstream of or within negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
IMP: Inferred from mutant phenotype
24274065 MGI
acts upstream of or within selenocysteine incorporation IMP
IMP: Inferred from mutant phenotype
24274065 MGI
acts upstream of or within striatum development IMP
IMP: Inferred from mutant phenotype
24844465 MGI
acts upstream of or within translation IMP
IMP: Inferred from mutant phenotype
27956496 MGI
Cellular Component GO Annotation Evidence References Source
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
22992746 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

selenocysteine insertion sequence-binding protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12626 SECISBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12627 SECISBP2L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Secisbp2 NCBI NCBI:79048