ZFX - zinc finger protein X-linked Gene

Also Known as ZNF926

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7543

About ZFX

Cytogenetic location: Xp22.11 Genomic coordinates (GRCh38): X:24,148,982-24,216,255 (from NCBI)

This gene has 11 transcripts (splice variants), 107 orthologues and 38 paralogues. Ubiquitous expression in endometrium (RPKM 5.2), thyroid (RPKM 4.9) and 25 other tissues.

Summary

This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]

ZFX Products (6)

mRNA Protein Name
NM_001178084.2 NP_001171555.1 zinc finger X-chromosomal protein isoform 1
NM_001178085.1 NP_001171556.1 zinc finger X-chromosomal protein isoform 1
NM_001178086.2 NP_001171557.1 zinc finger X-chromosomal protein isoform 2
NM_001178095.2 NP_001171566.1 zinc finger X-chromosomal protein isoform 3
NM_001330327.2 NP_001317256.1 zinc finger X-chromosomal protein isoform 4
NM_003410.4 NP_003401.2 zinc finger X-chromosomal protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
24831540 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
38325380 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
24831540 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24831540 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
24831540 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFX Protein Structure

Zfx_Zfy_act

Zfx_Zfy_act: Zfx / Zfy transcription activation region (69 - 410)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (425 - 447)

zf-H2C2_5

zf-H2C2_5: C2H2-type zinc-finger domain (456 - 478)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (489 - 510)

zf-H2C2_5

zf-H2C2_5: C2H2-type zinc-finger domain (519 - 542)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (563 - 584)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (590 - 615)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (647 - 672)

zf-H2C2_5

zf-H2C2_5: C2H2-type zinc-finger domain (690 - 714)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (734 - 757)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (776 - 798)

  • 0
  • 200
  • 400
  • 600
  • 805 a.a.
Protein Preferred Names Protein Names

zinc finger X-chromosomal protein

  • X-linked zinc finger protein

Related Diseases

Diseases Alias
46,Xx Sex Reversal

  • 46,Xx Testicular Disorder Of Sex Development

  • 46,Xx Testicular Dsd

  • De La Chapelle Syndrome

  • Srxx

  • Xx, Male Syndrome

  • 46, Xx Testicular Disorders Of Sex Development
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16053 ZFX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20687 Zfx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27198 Zfx Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZFX RGD RGD:1562664
Mus musculus ZFX MGD MGI:99211
Others ZFX NCBI