Amotl1 - angiomotin-like 1 Gene

Also Known as JEAP; mFLJ00155; 2310010G08Rik; 2310067L22Rik; 4932416D09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 75723

Summary

Predicted to enable identical protein binding activity. Acts upstream of or within establishment of cell polarity involved in ameboidal cell migration and positive regulation of blood vessel endothelial cell migration. Located in several cellular components, including apical plasma membrane; bicellular tight junction; and lamellipodium. Is expressed in brain and head. Orthologous to human AMOTL1 (angiomotin like 1). [provided by Alliance of Genome Resources, Apr 2022]

Amotl1 Products (1)

mRNA Protein Name
NM_001081395.1 NP_001074864.1 angiomotin-like protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17397395 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of blood vessel endothelial cell migration IMP
IMP: Inferred from mutant phenotype
19590046 MGI
acts upstream of or within establishment of cell polarity involved in ameboidal cell migration IMP
IMP: Inferred from mutant phenotype
19590046 MGI
acts upstream of or within positive regulation of blood vessel endothelial cell migration IMP
IMP: Inferred from mutant phenotype
19590046 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
17397395 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
11733531 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
17397395 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
19590046 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

angiomotin-like protein 1

  • junction-enriched and -associated protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00664 AMOTL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Amotl1 NCBI NCBI:154810