Dock8 - dedicator of cytokinesis 8 Gene

Also Known as 1200017A24Rik; 5830472H07Rik; A130095G14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 76088

Summary

Enables guanyl-nucleotide exchange factor activity. Involved in dendritic cell migration; positive regulation of T cell migration; and positive regulation of establishment of T cell polarity. Acts upstream of or within immunological synapse formation and negative regulation of T cell apoptotic process. Located in cell leading edge. Is expressed in central nervous system; retina; and thymus primordium. Human ortholog(s) of this gene implicated in atopic dermatitis; Bacterial infectious disease; hyper IgE recurrent Infection syndrome 2; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; and viral infectious disease (multiple). Orthologous to human DOCK8 (dedicator of cytokinesis 8). [provided by Alliance of Genome Resources, Apr 2022]

Dock8 Products (1)

mRNA Protein Name
NM_028785.3 NP_083061.2 dedicator of cytokinesis protein 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
22461490 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
28028151 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within dendritic cell migration IGI
IGI: Inferred from genetic interaction
22461490 MGI
acts upstream of or within dendritic cell migration IMP
IMP: Inferred from mutant phenotype
22461490 MGI
involved in dendritic cell migration IMP
IMP: Inferred from mutant phenotype
25713392 MGI
acts upstream of or within immunological synapse formation IMP
IMP: Inferred from mutant phenotype
22006977 MGI
acts upstream of or within negative regulation of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
21969276 MGI
involved in positive regulation of T cell migration IMP
IMP: Inferred from mutant phenotype
28028151 MGI
involved in positive regulation of establishment of T cell polarity IMP
IMP: Inferred from mutant phenotype
28028151 MGI
Cellular Component GO Annotation Evidence References Source
located in cell leading edge IDA
IDA: Inferred from direct assay
22461490 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dedicator of cytokinesis protein 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03930 DOCK8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dock8 NCBI NCBI:81704