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Rapgef2 - Rap guanine nucleotide exchange factor (GEF) 2 Gene

Also Known as Pdzgef1; nRapGEP; CNRasGEF; RA-GEF-1; mKIAA0313; 5830453M24Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 76089

Summary

Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including cAMP-mediated signaling; cellular response to cAMP; and generation of neurons. Predicted to be located in several cellular components, including apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Predicted to be part of protein-containing complex. Is expressed in embryo; olfactory epithelium; yolk sac endoderm; and yolk sac mesenchyme. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 7. Orthologous to human RAPGEF2 (Rap guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Rapgef2 Products (2)

mRNA	Protein	Name
NM_001099624.3	NP_001093094.2	rap guanine nucleotide exchange factor 2 isoform 1
NM_001310536.2	NP_001297465.2	rap guanine nucleotide exchange factor 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	23800469	MGI
enables guanyl-nucleotide exchange factor activity	IMP IMP: Inferred from mutant phenotype	16272156	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	23800469	MGI
involved in blood vessel development	IMP IMP: Inferred from mutant phenotype	17826737	MGI
involved in cAMP-mediated signaling	IDA IDA: Inferred from direct assay	23800469	MGI
involved in cellular response to cAMP	IDA IDA: Inferred from direct assay	23800469	MGI
involved in cellular response to cAMP	IMP IMP: Inferred from mutant phenotype	16272156	MGI
involved in forebrain neuron development	IMP IMP: Inferred from mutant phenotype	19453629	MGI
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16272156	MGI
involved in negative regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	16272156	MGI
involved in negative regulation of melanin biosynthetic process	IMP IMP: Inferred from mutant phenotype	16272156	MGI
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	21864586	MGI
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	23800469	MGI
involved in neuropeptide signaling pathway	IDA IDA: Inferred from direct assay	23800469	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	23800469	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	16272156	MGI
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	23800469	MGI
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	16272156	MGI
involved in positive regulation of cAMP-dependent protein kinase activity	IMP IMP: Inferred from mutant phenotype	16272156	MGI
involved in positive regulation of dendritic cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16272156	MGI
involved in positive regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	19453629	MGI
involved in positive regulation of protein binding	IDA IDA: Inferred from direct assay	23800469	MGI
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	23800469	MGI
involved in positive regulation of vasculogenesis	IMP IMP: Inferred from mutant phenotype	19635461	MGI
involved in regulation of modification of postsynaptic structure	IDA IDA: Inferred from direct assay	26490870	MGI
involved in regulation of modification of postsynaptic structure	IEP IEP: Inferred from expression pattern	26490870	MGI
involved in regulation of modification of postsynaptic structure	IMP IMP: Inferred from mutant phenotype	26490870	MGI
involved in ventricular system development	IMP IMP: Inferred from mutant phenotype	17826737	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in postsynapse	IDA IDA: Inferred from direct assay	26490870	MGI
is active in postsynapse	IEP IEP: Inferred from expression pattern	26490870	MGI
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	26490870	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
rap guanine nucleotide exchange factor 2	PDZ domain-containing guanine nucleotide exchange factor 1 cyclic nucleotide ras GEF neural RAP guanine nucleotide exchange protein ras/Rap1-associating GEF-1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11661	RAPGEF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rapgef2	NCBI	NCBI:9693