Rhbdd1 - rhomboid domain containing 1 Gene

Also Known as RRP4; mRHBDD1; 4930418P06Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 76867

Summary

Enables peptidase activity. Involved in several processes, including cellular response to unfolded protein; membrane protein proteolysis; and positive regulation of protein processing. Located in endoplasmic reticulum membrane and endoplasmic reticulum quality control compartment. Is integral component of endoplasmic reticulum membrane. Orthologous to human RHBDD1 (rhomboid domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Rhbdd1 Products (2)

mRNA	Protein	Name
NM_001122685.1	NP_001116157.1	rhomboid-related protein 4
NM_029777.3	NP_084053.3	rhomboid-related protein 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables peptidase activity	IDA IDA: Inferred from direct assay	22795130	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18953687	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in ERAD pathway	IDA IDA: Inferred from direct assay	22795130	MGI
involved in cellular response to UV	IDA IDA: Inferred from direct assay	19358743	MGI
involved in cellular response to unfolded protein	IDA IDA: Inferred from direct assay	22795130	MGI
involved in membrane protein intracellular domain proteolysis	IDA IDA: Inferred from direct assay	22795130	MGI
involved in membrane protein proteolysis involved in retrograde protein transport, ER to cytosol	IDA IDA: Inferred from direct assay	22795130	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19358743	MGI
involved in positive regulation of protein processing	IDA IDA: Inferred from direct assay	22795130	MGI
involved in post-translational protein modification	IDA IDA: Inferred from direct assay	22795130	MGI
NOT involved in regulation of male germ cell proliferation	IMP IMP: Inferred from mutant phenotype	19358743	MGI
involved in spermatid differentiation	IMP IMP: Inferred from mutant phenotype	19358743	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	22795130	MGI
located in endoplasmic reticulum quality control compartment	IDA IDA: Inferred from direct assay	22795130	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
rhomboid-related protein 4	rhomboid domain-containing protein 1 rhomboid-like protein 4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11931	RHBDD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rhbdd1	NCBI	NCBI:84236