Mtmr2 - myotubularin related protein 2 Gene

Also Known as 6030445P13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 77116

Summary

Enables identical protein binding activity and phosphatidylinositol phosphate Phosphatase activity. Acts upstream of or within dephosphorylation; negative regulation of myelination; and nervous system development. Located in vacuolar membrane. Is expressed in several structures, including eye; genitourinary system; gut; immune system; and nervous system. Used to study Charcot-Marie-Tooth disease type 4B1. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4B1. Orthologous to human MTMR2 (myotubularin related protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Mtmr2 Products (8)

mRNA Protein Name
NM_001372573.1 NP_001359502.1 myotubularin-related protein 2 isoform 2
NM_001373873.1 NP_001360802.1 myotubularin-related protein 2 isoform 3
NM_001373874.1 NP_001360803.1 myotubularin-related protein 2 isoform 4
NM_001373875.1 NP_001360804.1 myotubularin-related protein 2 isoform 2
NM_001373876.1 NP_001360805.1 myotubularin-related protein 2 isoform 2
NM_001373877.1 NP_001360806.1 myotubularin-related protein 2 isoform 2
NM_001373878.1 NP_001360807.1 myotubularin-related protein 2 isoform 2
NM_023858.4 NP_076347.3 myotubularin-related protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16399794 MGI
enables phosphatidylinositol phosphate phosphatase activity IMP
IMP: Inferred from mutant phenotype
22028665 MGI
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IDA
IDA: Inferred from direct assay
12045210 MGI
enables phosphatidylinositol-3-phosphate phosphatase activity IDA
IDA: Inferred from direct assay
12045210 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16399794 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within dephosphorylation IDA
IDA: Inferred from direct assay
16399794 MGI
acts upstream of or within myelin assembly IGI
IGI: Inferred from genetic interaction
22028665 MGI
acts upstream of or within myelin assembly IMP
IMP: Inferred from mutant phenotype
22028665 MGI
acts upstream of myelination IGI
IGI: Inferred from genetic interaction
22028665 MGI
acts upstream of or within negative regulation of myelination IGI
IGI: Inferred from genetic interaction
22028665 MGI
acts upstream of or within negative regulation of myelination IMP
IMP: Inferred from mutant phenotype
19587293 MGI
acts upstream of or within neuron development IGI
IGI: Inferred from genetic interaction
22028665 MGI
acts upstream of or within phosphatidylinositol dephosphorylation IDA
IDA: Inferred from direct assay
16399794 MGI
acts upstream of or within phosphatidylinositol metabolic process IMP
IMP: Inferred from mutant phenotype
22028665 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12837694 MGI
located in vacuolar membrane IDA
IDA: Inferred from direct assay
16399794 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myotubularin-related protein 2

  • phosphatidylinositol-3,5-bisphosphate 3-phosphatase

  • phosphatidylinositol-3-phosphate phosphatase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08789 MTMR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mtmr2 NCBI NCBI:8898