Heg1 - heart development protein with EGF-like domains 1 Gene

Mus musculus

Also known as Gm629; 4632417D23Rik; 5530401I02Rik; 9530025L16Rik

Gene ID: 77446 | Gene type: protein coding

About Heg1

Summary

Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including circulatory system development; endothelial cell morphogenesis; and lymph circulation. Located in cell-cell junction and external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human HEG1 (heart development protein with EGF like domains 1). [provided by Alliance of Genome Resources, Apr 2022]

Heg1 Products(1)

mRNA	Protein	Name
NM_175256.5	NP_780465.4	protein HEG homolog 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19151727	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cardiac atrium morphogenesis	IGI IGI: Inferred from genetic interaction	22898778	MGI
acts upstream of or within cardiac atrium morphogenesis	IMP IMP: Inferred from mutant phenotype	19151727	MGI
acts upstream of or within cardiac muscle tissue growth	IGI IGI: Inferred from genetic interaction	22898778	MGI
acts upstream of or within cell-cell junction organization	IMP IMP: Inferred from mutant phenotype	19151727	MGI
acts upstream of or within endothelial cell development	IGI IGI: Inferred from genetic interaction	19151727	MGI
acts upstream of or within endothelial cell morphogenesis	IMP IMP: Inferred from mutant phenotype	19151727	MGI
acts upstream of fibroblast growth factor production	IGI IGI: Inferred from genetic interaction	22898778	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	19151727	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	19151727	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	19151727	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	19151727	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	19151727	MGI
acts upstream of or within lymph circulation	IMP IMP: Inferred from mutant phenotype	19151727	MGI
acts upstream of or within lymph vessel development	IMP IMP: Inferred from mutant phenotype	19151727	MGI
acts upstream of or within multicellular organism growth	IGI IGI: Inferred from genetic interaction	19151727	MGI
acts upstream of or within pericardium development	IGI IGI: Inferred from genetic interaction	19151727	MGI
acts upstream of or within pericardium development	IMP IMP: Inferred from mutant phenotype	19151727	MGI
acts upstream of or within positive regulation of fibroblast growth factor production	IGI IGI: Inferred from genetic interaction	22898778	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	19151727	MGI
acts upstream of or within regulation of body fluid levels	IMP IMP: Inferred from mutant phenotype	19151727	MGI
acts upstream of or within vasculature development	IGI IGI: Inferred from genetic interaction	19151727	MGI
acts upstream of or within vasculogenesis	IGI IGI: Inferred from genetic interaction	19151727	MGI
acts upstream of or within venous blood vessel morphogenesis	IGI IGI: Inferred from genetic interaction	19151727	MGI
acts upstream of or within ventricular septum development	IMP IMP: Inferred from mutant phenotype	19151727	MGI
acts upstream of or within ventricular trabecula myocardium morphogenesis	IGI IGI: Inferred from genetic interaction	22898778	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	19151727	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	19151727	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	19151727	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein HEG homolog 1

HEG homolog 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06113	HEG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Heg1	NCBI	NCBI:57493

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