Smpd4 - sphingomyelin phosphodiesterase 4 Gene

Also Known as 4122402O22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 77626

Summary

Enables sphingomyelin phosphodiesterase activity. Involved in cellular response to tumor necrosis factor; ceramide biosynthetic process; and sphingomyelin catabolic process. Acts upstream of or within in utero embryonic development. Located in endoplasmic reticulum; nuclear envelope; and sarcolemma. Is expressed in cranium; hemolymphoid system; nervous system; respiratory system; and urinary system. Orthologous to human SMPD4 (sphingomyelin phosphodiesterase 4). [provided by Alliance of Genome Resources, Apr 2022]

Smpd4 Products (5)

mRNA Protein Name
NM_001164609.2 NP_001158081.1 sphingomyelin phosphodiesterase 4 isoform 4
NM_001164610.2 NP_001158082.1 sphingomyelin phosphodiesterase 4 isoform 3
NM_001164611.2 NP_001158083.1 sphingomyelin phosphodiesterase 4 isoform 2
NM_001403422.1 NP_001390351.1 sphingomyelin phosphodiesterase 4 isoform 3
NM_029945.4 NP_084221.2 sphingomyelin phosphodiesterase 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables sphingomyelin phosphodiesterase activity IDA
IDA: Inferred from direct assay
25180167 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
25180167 MGI
involved in ceramide biosynthetic process IDA
IDA: Inferred from direct assay
25180167 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
27996060 MGI
involved in sphingomyelin catabolic process IDA
IDA: Inferred from direct assay
25180167 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
25180167 MGI
located in nuclear envelope IDA
IDA: Inferred from direct assay
31142202 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
25180167 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sphingomyelin phosphodiesterase 4

  • nSMase3

  • neutral membrane (neutral sphingomyelinase-3)

  • neutral sphingomyelinase 3

  • neutral sphingomyelinase III

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13450 SMPD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smpd4 NCBI NCBI:55627