Rnf170 - ring finger protein 170 Gene

Also Known as 6720407G21Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 77733

Summary

Predicted to enable metal ion binding activity and ubiquitin protein Ligase activity. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Used to study hereditary ataxia. Human ortholog(s) of this gene implicated in autosomal dominant sensory ataxia 1. Orthologous to human RNF170 (ring finger protein 170). [provided by Alliance of Genome Resources, Apr 2022]

Rnf170 Products (5)

mRNA	Protein	Name
NM_001357292.1	NP_001344221.1	E3 ubiquitin-protein ligase RNF170 isoform 2
NM_001357293.2	NP_001344222.2	E3 ubiquitin-protein ligase RNF170 isoform 1
NM_001357294.2	NP_001344223.2	E3 ubiquitin-protein ligase RNF170 isoform 1
NM_001357295.2	NP_001344224.2	E3 ubiquitin-protein ligase RNF170 isoform 1
NM_029965.4	NP_084241.2	E3 ubiquitin-protein ligase RNF170 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	31076723	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	31076723	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	26433933	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	26433933	MGI
acts upstream of or within innate immune response	IMP IMP: Inferred from mutant phenotype	31076723	MGI
acts upstream of or within proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	31076723	MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	31076723	MGI
acts upstream of or within protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	31076723	MGI
acts upstream of or within protein K48-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	31076723	MGI
acts upstream of or within protein catabolic process	IMP IMP: Inferred from mutant phenotype	31076723	MGI
acts upstream of or within protein polyubiquitination	IDA IDA: Inferred from direct assay	31076723	MGI
acts upstream of or within response to activity	IMP IMP: Inferred from mutant phenotype	26433933	MGI
acts upstream of or within response to temperature stimulus	IMP IMP: Inferred from mutant phenotype	26433933	MGI
acts upstream of or within toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	31076723	MGI
acts upstream of or within walking behavior	IMP IMP: Inferred from mutant phenotype	26433933	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RNF170	RING-type E3 ubiquitin transferase RNF170

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12065	RNF170 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rnf170	NCBI	NCBI:81790