Adamtsl2 - ADAMTS-like 2 Gene

Also Known as tcp-1; A930008K15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 77794

Summary

Enables microfibril binding activity. Acts upstream of or within extracellular matrix organization; lobar bronchus epithelium development; and negative regulation of transforming growth factor beta receptor signaling pathway. Located in extracellular matrix and extracellular region. Is expressed in several structures, including cardiovascular system; limb; lung; musculoskeletal system; and tail mesenchyme. Used to study geleophysic dysplasia 1. Human ortholog(s) of this gene implicated in geleophysic dysplasia 1. Orthologous to human ADAMTSL2 (ADAMTS like 2). [provided by Alliance of Genome Resources, Apr 2022]

Adamtsl2 Products (1)

mRNA Protein Name
NM_029981.2 NP_084257.1 ADAMTS-like protein 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables microfibril binding IPI
IPI: Inferred from physical interaction
25762570 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
29758265 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
25762570 MGI
acts upstream of or within lobar bronchus epithelium development IMP
IMP: Inferred from mutant phenotype
25762570 MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25762570 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
17509843 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
17509843 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ADAMTS-like protein 2

  • TSP1-repeat-containing protein 1

  • TSP1-repeats-containing protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00311 ADAMTSL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adamtsl2 NCBI NCBI:9719