Rdh12 - retinol dehydrogenase 12 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 77974

Summary

The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in the human gene are associated with Leber congenital amaurosis type 13, and Retinitis Pigmentosa 53. [provided by RefSeq, Sep 2015]

Rdh12 Products (2)

mRNA Protein Name
NM_001313971.1 NP_001300900.1 retinol dehydrogenase 12 isoform 2 precursor
NM_030017.4 NP_084293.1 retinol dehydrogenase 12 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables all-trans-retinol dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
22621924 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular detoxification of aldehyde IDA
IDA: Inferred from direct assay
22621924 MGI
involved in retinol metabolic process IDA
IDA: Inferred from direct assay
22621924 MGI
involved in visual perception IMP
IMP: Inferred from mutant phenotype
17032653 MGI
Cellular Component GO Annotation Evidence References Source
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
12226107 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

retinol dehydrogenase 12

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11800 RDH12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rdh12 NCBI NCBI:145226