Rdh12 - retinol dehydrogenase 12 Gene

Mus musculus

Gene ID: 77974 | Gene type: protein coding

About Rdh12

Summary

The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in the human gene are associated with Leber congenital amaurosis type 13, and Retinitis Pigmentosa 53. [provided by RefSeq, Sep 2015]

Rdh12 Products(2)

mRNA	Protein	Name
NM_001313971.1	NP_001300900.1	retinol dehydrogenase 12 isoform 2 precursor
NM_030017.4	NP_084293.1	retinol dehydrogenase 12 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables all-trans-retinol dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	22621924	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular detoxification of aldehyde	IDA IDA: Inferred from direct assay	22621924	MGI
involved in retinol metabolic process	IDA IDA: Inferred from direct assay	22621924	MGI
involved in visual perception	IMP IMP: Inferred from mutant phenotype	17032653	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	12226107	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

retinol dehydrogenase 12

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11800	RDH12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rdh12	NCBI	NCBI:145226

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