Adgra2 - adhesion G protein-coupled receptor A2 Gene

Also Known as Tem5; Gpr124; mKIAA1531; 8430414O08Rik; 9530074E10Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 78560

Summary

Predicted to enable G protein-coupled receptor activity. Involved in several processes, including endothelial cell migration; positive regulation of canonical Wnt signaling pathway; and sprouting angiogenesis. Acts upstream of or within several processes, including negative regulation of vascular endothelial growth factor signaling pathway; positive regulation of endothelial cell migration; and regulation of establishment of blood-brain barrier. Located in cell surface and plasma membrane. Is expressed in several structures, including cardiovascular system; embryo mesenchyme; limb bud; mesonephros; and nose. Orthologous to human ADGRA2 (adhesion G protein-coupled receptor A2). [provided by Alliance of Genome Resources, Apr 2022]

Adgra2 Products (1)

mRNA	Protein	Name
NM_054044.2	NP_473385.2	adhesion G protein-coupled receptor A2 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	21421844	MGI
involved in central nervous system development	IMP IMP: Inferred from mutant phenotype	21071672	MGI
involved in endothelial cell migration	IMP IMP: Inferred from mutant phenotype	21071672	MGI
acts upstream of or within negative regulation of vascular endothelial growth factor signaling pathway	IMP IMP: Inferred from mutant phenotype	21421844	MGI
involved in positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	28803732	MGI
acts upstream of or within positive regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	21421844	MGI
involved in regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	21071672	MGI
involved in regulation of chemotaxis	IMP IMP: Inferred from mutant phenotype	21071672	MGI
acts upstream of or within regulation of establishment of blood-brain barrier	IMP IMP: Inferred from mutant phenotype	21421844	MGI
involved in regulation of establishment of blood-brain barrier	IMP IMP: Inferred from mutant phenotype	28288111	MGI
acts upstream of or within sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	23918385	MGI
involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	21071672	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	21421844	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	28803732	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
adhesion G protein-coupled receptor A2	G protein coupled receptor Gpr124 G-protein coupled receptor 124 tumor endothelial marker 5

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00343	ADGRA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adgra2	NCBI	NCBI:25960