Stxbp5 - syntaxin binding protein 5 (tomosyn) Gene

Also Known as LGL3; mKIAA1006; 0710001E20Rik; 4930565N16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 78808

Summary

Enables syntaxin-1 binding activity. Involved in positive regulation of exocytosis; regulation of synaptic vesicle exocytosis; and regulation of synaptic vesicle priming. Acts upstream of or within exocytosis and regulation of exocytosis. Part of acetylcholine-gated channel complex. Is active in hippocampal mossy fiber to CA3 synapse and presynapse. Is extrinsic component of neuronal dense core vesicle membrane. Orthologous to human STXBP5 (syntaxin binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]

Stxbp5 Products (4)

mRNA Protein Name
NM_001081344.3 NP_001074813.2 syntaxin-binding protein 5 isoform 1
NM_001408063.1 NP_001394992.1 syntaxin-binding protein 5 isoform 2
NM_001408064.1 NP_001394993.1 syntaxin-binding protein 5 isoform 3
NM_001408065.1 NP_001394994.1 syntaxin-binding protein 5 isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12832401 MGI
enables syntaxin binding IPI
IPI: Inferred from physical interaction
12832401 MGI
enables syntaxin-1 binding IDA
IDA: Inferred from direct assay
16787939 MGI
enables syntaxin-1 binding IPI
IPI: Inferred from physical interaction
12832401 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within exocytosis IDA
IDA: Inferred from direct assay
12832401 MGI
involved in positive regulation of exocytosis IDA
IDA: Inferred from direct assay
16787939 MGI
acts upstream of or within regulation of exocytosis IDA
IDA: Inferred from direct assay
21330375 MGI
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
18936251 MGI
involved in regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
18936251 MGI
involved in regulation of synaptic vesicle priming IDA
IDA: Inferred from direct assay
18936251 MGI
involved in regulation of synaptic vesicle priming IEP
IEP: Inferred from expression pattern
18936251 MGI
involved in regulation of synaptic vesicle priming IMP
IMP: Inferred from mutant phenotype
18936251 MGI
Cellular Component GO Annotation Evidence References Source
part of acetylcholine-gated channel complex IDA
IDA: Inferred from direct assay
12832401 MGI
is active in extrinsic component of neuronal dense core vesicle membrane IDA
IDA: Inferred from direct assay
28746398 MGI
is active in extrinsic component of neuronal dense core vesicle membrane IMP
IMP: Inferred from mutant phenotype
28746398 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
18936251 MGI
is active in hippocampal mossy fiber to CA3 synapse IEP
IEP: Inferred from expression pattern
18936251 MGI
is active in hippocampal mossy fiber to CA3 synapse IMP
IMP: Inferred from mutant phenotype
18936251 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
28746398 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

syntaxin-binding protein 5

  • lethal(2) giant larvae protein homolog 3

  • tomosyn-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13993 STXBP5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13994 STXBP5L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stxbp5 NCBI NCBI:134957