Stxbp5 - syntaxin binding protein 5 (tomosyn) Gene

Mus musculus

Also known as LGL3; mKIAA1006; 0710001E20Rik; 4930565N16Rik

Gene ID: 78808 | Gene type: protein coding

About Stxbp5

Summary

Enables syntaxin-1 binding activity. Involved in positive regulation of exocytosis; regulation of synaptic vesicle exocytosis; and regulation of synaptic vesicle priming. Acts upstream of or within exocytosis and regulation of exocytosis. Part of acetylcholine-gated channel complex. Is active in hippocampal mossy fiber to CA3 synapse and presynapse. Is extrinsic component of neuronal dense core vesicle membrane. Orthologous to human STXBP5 (syntaxin binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]

Stxbp5 Products(4)

mRNA	Protein	Name
NM_001081344.3	NP_001074813.2	syntaxin-binding protein 5 isoform 1
NM_001408063.1	NP_001394992.1	syntaxin-binding protein 5 isoform 2
NM_001408064.1	NP_001394993.1	syntaxin-binding protein 5 isoform 3
NM_001408065.1	NP_001394994.1	syntaxin-binding protein 5 isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12832401	MGI
enables syntaxin binding	IPI IPI: Inferred from physical interaction	12832401	MGI
enables syntaxin-1 binding	IDA IDA: Inferred from direct assay	16787939	MGI
enables syntaxin-1 binding	IPI IPI: Inferred from physical interaction	12832401	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within exocytosis	IDA IDA: Inferred from direct assay	12832401	MGI
involved in positive regulation of exocytosis	IDA IDA: Inferred from direct assay	16787939	MGI
acts upstream of or within regulation of exocytosis	IDA IDA: Inferred from direct assay	21330375	MGI
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	18936251	MGI
involved in regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	18936251	MGI
involved in regulation of synaptic vesicle priming	IDA IDA: Inferred from direct assay	18936251	MGI
involved in regulation of synaptic vesicle priming	IEP IEP: Inferred from expression pattern	18936251	MGI
involved in regulation of synaptic vesicle priming	IMP IMP: Inferred from mutant phenotype	18936251	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of acetylcholine-gated channel complex	IDA IDA: Inferred from direct assay	12832401	MGI
is active in extrinsic component of neuronal dense core vesicle membrane	IDA IDA: Inferred from direct assay	28746398	MGI
is active in extrinsic component of neuronal dense core vesicle membrane	IMP IMP: Inferred from mutant phenotype	28746398	MGI
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	18936251	MGI
is active in hippocampal mossy fiber to CA3 synapse	IEP IEP: Inferred from expression pattern	18936251	MGI
is active in hippocampal mossy fiber to CA3 synapse	IMP IMP: Inferred from mutant phenotype	18936251	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	28746398	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

syntaxin-binding protein 5

lethal(2) giant larvae protein homolog 3

tomosyn-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13993	STXBP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13994	STXBP5L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stxbp5	NCBI	NCBI:134957

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