Pigt - phosphatidylinositol glycan anchor biosynthesis, class T Gene

Also Known as NDAP; Ndap7; CGI-06; 2510012P17Rik; 4930534E15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 78928

Summary

Involved in attachment of GPI anchor to protein. Acts upstream of or within neuron apoptotic process and neuron differentiation. Located in cytoplasmic vesicle. Part of GPI-anchor transamidase complex. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 3 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGT (phosphatidylinositol glycan anchor biosynthesis class T). [provided by Alliance of Genome Resources, Apr 2022]

Pigt Products (5)

mRNA Protein Name
NM_001362644.2 NP_001349573.1 GPI transamidase component PIG-T isoform 2 precursor
NM_001362645.2 NP_001349574.1 GPI transamidase component PIG-T isoform 3
NM_001378795.1 NP_001365724.1 GPI transamidase component PIG-T isoform 4
NM_001407281.1 NP_001394210.1 GPI transamidase component PIG-T isoform 1 precursor
NM_133779.3 NP_598540.2 GPI transamidase component PIG-T isoform 1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in attachment of GPI anchor to protein IMP
IMP: Inferred from mutant phenotype
11483512 MGI
acts upstream of or within neuron apoptotic process IDA
IDA: Inferred from direct assay
16516892 MGI
acts upstream of or within neuron differentiation IDA
IDA: Inferred from direct assay
16516892 MGI
Cellular Component GO Annotation Evidence References Source
part of GPI-anchor transamidase complex IDA
IDA: Inferred from direct assay
11483512 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16516892 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
16516892 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GPI transamidase component PIG-T

  • neuronal development-associated protein 7

  • phosphatidylinositol-glycan biosynthesis class T protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10502 PIGT Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pigt NCBI NCBI:51604