IRX1 - iroquois homeobox 1 Gene

Also Known as IRX-5; IRXA1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79192

About IRX1

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:3,595,832-3,601,403 (from NCBI)

This gene has 1 transcript (splice variant), 186 orthologues and 6 paralogues. Biased expression in kidney (RPKM 2.5), salivary gland (RPKM 1.1) and 4 other tissues.

Summary

This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Dec 2011]

IRX1 Products (1)

mRNA Protein Name
NM_024337.4 NP_077313.3 iroquois-class homeodomain protein IRX-1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
20440264 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20440264 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRX1 Protein Structure

Homeobox_KN

Homeobox_KN: Homeobox KN domain (145 - 184)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 480 a.a.
Protein Preferred Names Protein Names

iroquois-class homeodomain protein IRX-1

  • homeodomain protein IRXA1

Related Diseases

Diseases Alias
Pulmonary Immaturity

  • Primary Atelectasis Of Newborn

  • Primary Atelectasis, In Perinatal Period

  • Primary Failure To Expand Terminal Respiratory Units

  • Immature Lungs

  • Primary Atelectasis

  • Pulmonary Immaturity Nos

  • Lung Lobe Hypoplasia, Associated With Short Gestation

  • Lung Nonexpansion

  • Premature Lungs

  • Pulmonary Hypoplasia Associated With Short Gestation

  • Failure Of Expansion Of Terminal Respiratory Units

  • Primary Atelectasis Of Fetus Or Newborn

  • Primary Atelectasis In Perinatal Period
Scoliosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06920 IRX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06922 IRX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus IRX1 VGNC VGNC:30286
Felis catus IRX1 VGNC VGNC:102235
Mus musculus IRX1 MGD MGI:1197515
Macaca mulatta IRX1 VGNC VGNC:73591
Rattus norvegicus IRX1 RGD RGD:1309060
Others IRX1 NCBI