Gja3 - gap junction protein, alpha 3 Gene

Rattus norvegicus

Also known as Cxnj1

Gene ID: 79217 | Gene type: protein coding

About Gja3

Summary

Enables gap junction hemi-channel activity and identical protein binding activity. Involved in response to hydrogen peroxide and response to pH. Located in gap junction and membrane raft. Used to study cataract. Human ortholog(s) of this gene implicated in cataract 14 multiple types. Orthologous to human GJA3 (Gap Junction Protein alpha 3). [provided by Alliance of Genome Resources, Apr 2022]

Gja3 Products(1)

mRNA	Protein	Name
NM_024376.3	NP_077352.2	gap junction alpha-3 protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables gap junction channel activity	IDA IDA: Inferred from direct assay	1659572	RGD
enables gap junction hemi-channel activity	IDA IDA: Inferred from direct assay	17715132	RGD
enables identical protein binding	IDA IDA: Inferred from direct assay	9151687	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15467523	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in response to hydrogen peroxide	IDA IDA: Inferred from direct assay	15467523	RGD
involved in response to pH	IDA IDA: Inferred from direct assay	11889584	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in gap junction	IDA IDA: Inferred from direct assay	1659572	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gap junction alpha-3 protein

connexin j1	connexin-46
cx46	gap junction membrane channel protein alpha 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05442	GJA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gja3	NCBI	NCBI:2700

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