2. Gene
  3. Gucy2d - guanylate cyclase 2D, retinal Gene

Gucy2d - guanylate cyclase 2D, retinal Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Gucy2e; RETGC-1

Gene ID: 79222 | Gene type: protein coding

About Gucy2d

Summary

Enables Guanylate Cyclase activity and protein homodimerization activity. Involved in cGMP-mediated signaling. Located in photoreceptor outer segment membrane. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 1; choroidal sclerosis; cone-rod dystrophy 6; congenital stationary night blindness; and retinitis pigmentosa. Orthologous to human GUCY2D (Guanylate Cyclase 2D, retinal). [provided by Alliance of Genome Resources, Apr 2022]

Gucy2d Products(1)

mRNA Protein Name
NM_024380.1 NP_077356.1 retinal guanylyl cyclase 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables guanylate cyclase activity IDA
IDA: Inferred from direct assay
7831337 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
9153227 RGD
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
9153227 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
9153227 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cGMP-mediated signaling IDA
IDA: Inferred from direct assay
9153227 RGD
Cellular Component GO Annotation Evidence Reference Source
located in photoreceptor outer segment membrane IDA
IDA: Inferred from direct assay
9153227 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

retinal guanylyl cyclase 1

guanylate cyclase 2D, membrane (retina-specific)

guanylate cyclase 2E

guanylyl cyclase 2e

guanylyl cyclase GC-E

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05922 GUCY2D Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gucy2d NCBI NCBI:3000