Hnrnpd - heterogeneous nuclear ribonucleoprotein D Gene

Rattus norvegicus

Also known as Auf1; Hnrpd

Gene ID: 79256 | Gene type: protein coding

About Hnrnpd

Summary

Enables chromatin binding activity; histone deacetylase binding activity; and nucleic acid binding activity. Involved in several processes, including cellular response to estradiol stimulus; cellular response to organonitrogen compound; and regulation of mRNA stability. Located in cytosol and nucleus. Used to study uremia. Biomarker of hepatocellular carcinoma. Orthologous to human HNRNPD (heterogeneous nuclear ribonucleoprotein D). [provided by Alliance of Genome Resources, Apr 2022]

Hnrnpd Products(4)

mRNA	Protein	Name
NM_001082539.1	NP_001076008.1	heterogeneous nuclear ribonucleoprotein D0 isoform b
NM_001082540.1	NP_001076009.1	heterogeneous nuclear ribonucleoprotein D0 isoform c
NM_001082541.1	NP_001076010.1	heterogeneous nuclear ribonucleoprotein D0 isoform d
NM_024404.2	NP_077380.2	heterogeneous nuclear ribonucleoprotein D0 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	18413351	RGD
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	18413351	RGD
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: Inferred from direct assay	16113063	RGD
enables mRNA binding	IDA IDA: Inferred from direct assay	18583400	RGD
enables minor groove of adenine-thymine-rich DNA binding	IDA IDA: Inferred from direct assay	18413351	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16518874	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in 3'-UTR-mediated mRNA destabilization	IMP IMP: Inferred from mutant phenotype	20805360	RGD
involved in cellular response to amino acid stimulus	IEP IEP: Inferred from expression pattern	16569663	RGD
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	22216273	RGD
involved in cellular response to nitric oxide	IDA IDA: Inferred from direct assay	16683234	RGD
involved in cellular response to putrescine	IDA IDA: Inferred from direct assay	20805360	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	19115409	RGD
involved in hepatocyte dedifferentiation	IEP IEP: Inferred from expression pattern	20102719	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	20102719	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16683234	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20102719	RGD
involved in response to calcium ion	IDA IDA: Inferred from direct assay	18583400	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	20375275	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	11742537	RGD
involved in response to rapamycin	IDA IDA: Inferred from direct assay	17603996	RGD
involved in response to sodium phosphate	IDA IDA: Inferred from direct assay	18583400	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	22238095	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22238095	RGD
is active in postsynaptic density	EXP EXP: Inferred from Experiment	22238095	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	22238095	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

heterogeneous nuclear ribonucleoprotein D0

AU-rich element RNA-binding factor 1	AU-rich element RNA-binding protein 1
RNA binding protein p45AUF1	hnRNP D0

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06267	HNRNPD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21865	Hnrnpd Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hnrnpd	NCBI	NCBI:3184

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