2. Gene
  3. Krit1 - KRIT1, ankyrin repeat containing Gene

Krit1 - KRIT1, ankyrin repeat containing Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ccm1; 2010007K12Rik; A630036P20Rik

Gene ID: 79264 | Gene type: protein coding

About Krit1

Summary

Predicted to enable microtubule binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in cell redox homeostasis; negative regulation of angiogenesis; and regulation of establishment of cell polarity. Acts upstream of or within positive regulation of protein binding activity. Located in cytoplasm. Part of protein-containing complex. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; eye; and reproductive system. Used to study cerebral cavernous malformation. Human ortholog(s) of this gene implicated in cerebral cavernous malformation and cerebral cavernous malformation 1. Orthologous to human KRIT1 (KRIT1 ankyrin repeat containing). [provided by Alliance of Genome Resources, Apr 2022]

Krit1 Products(2)

mRNA Protein Name
NM_001170552.1 NP_001164023.1 krev interaction trapped protein 1 isoform 2
NM_030675.3 NP_109600.2 krev interaction trapped protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16712798 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cell redox homeostasis IMP
IMP: Inferred from mutant phenotype
20668652 MGI
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
20616044 MGI
acts upstream of or within positive regulation of protein binding IDA
IDA: Inferred from direct assay
19151727 MGI
involved in regulation of establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
20332120 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22970292 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
19151727 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

krev interaction trapped protein 1

cerebral cavernous malformations 1 protein homolog

krev interaction trapped 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07431 KRIT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Krit1 NCBI NCBI:889