Lias - lipoic acid synthetase Gene

Also Known as LS; 7a5ex; lip-syn; 2900022L22Rik; 4933425M12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 79464

Summary

Enables lipoate synthase activity. Acts upstream of or within several processes, including lipoate biosynthetic process; neural tube closure; and response to lipopolysaccharide. Located in mitochondrion. Is expressed in alimentary system; liver; metanephros; salivary gland; and urinary system. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human LIAS (lipoic acid synthetase). [provided by Alliance of Genome Resources, Apr 2022]

Lias Products (2)

mRNA Protein Name
NM_001310612.1 NP_001297541.1 lipoyl synthase, mitochondrial isoform 2
NM_024471.5 NP_077791.1 lipoyl synthase, mitochondrial isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lipoate synthase activity IGI
IGI: Inferred from genetic interaction
11389890 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
18845616 MGI
acts upstream of or within lipoate biosynthetic process IGI
IGI: Inferred from genetic interaction
11389890 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
15755804 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
18845616 MGI
acts upstream of or within response to oxidative stress IMP
IMP: Inferred from mutant phenotype
18845616 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
11389890 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lipoyl synthase, mitochondrial

  • lipoate synthase

  • lipoic acid synthase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-178914 Copper ionophore I 99.9% Unkown
HY-RS07639 LIAS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16259 Lias Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24964 Lias Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lias NCBI NCBI:11019