country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

ATP13A3 - ATPase 13A3 Gene

Also Known as PPH5; AFURS1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79572

About ATP13A3

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:194,402,677-194,494,334 (from NCBI)

This gene has 15 transcripts (splice variants), 285 orthologues and 21 paralogues. Ubiquitous expression in thyroid (RPKM 24.7), appendix (RPKM 18.3) and 25 other tissues.

Summary

ATP13A3 is a member of the P-type ATPase family of proteins that transport a variety of cations across membranes. Other P-type ATPases include ATP7B (MIM 606882) and ATP7A (MIM 300011).[supplied by OMIM, Aug 2008]

ATP13A3 Products (3)

mRNA	Protein	Name
NM_001367549.1	NP_001354478.1	polyamine-transporting ATPase 13A3 isoform 2
NM_001374836.1	NP_001361765.1	polyamine-transporting ATPase 13A3 isoform 3
NM_024524.4	NP_078800.3	polyamine-transporting ATPase 13A3 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables P-type transmembrane transporter activity	IDA IDA: Inferred from direct assay	33310703	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in early endosome membrane	IDA IDA: Inferred from direct assay	29505581	GOA
located in late endosome membrane	IDA IDA: Inferred from direct assay	29505581	GOA
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	29505581	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP13A3 Protein Structure

P5-ATPase

Cation_ATPase_N

E1-E2_ATPase

HAD

0
200
400
600
800
1000
1226 a.a.

Protein Preferred Names	Protein Names
polyamine-transporting ATPase 13A3	ATPase family homolog up-regulated in senescence cells 1

Related Diseases

Diseases	Alias
Pulmonary Hypertension, Primary, 5	Pulmonary Hypertension, Primary, 5, Autosomal Recessive PPH5 Hypertension, Pulmonary, Primary, Type 5
Pulmonary Hypertension, Primary, 1	Pulmonary Arterial Hypertension Pah Idiopathic Pulmonary Arterial Hypertension Idiopathic Pulmonary Hypertension Primary Pulmonary Hypertension PPH1 Pulmonary Hypertension, Primary, Fenfluramine Or Dexfenfluramine-Associated Pulmonary Hypertension, Familial Primary, 1, With Or Without Hht Pph Familial Primary Pulmonary Hypertension Sporadic Primary Pulmonary Hypertension Pht Fpah Familial Pulmonary Arterial Hypertension Hereditary Pulmonary Arterial Hypertension Heritable Pulmonary Arterial Hypertension Ayerza Syndrome Fpph Ppht Ipah Primary Pulmonary Arterial Hypertension Pulmonary Hypertension, Familial Primary Hypertension, Pulmonary, Primary, Type 1 Ayerza'S Syndrome Pah - [Pulmonary Arterial Hypertension] Arrillaga Ayerza Syndrome
Pulmonary Venoocclusive Disease	Pulmonary Veno-Occlusive Disease Obstructive Disease Of The Pulmonary Veins Pvod Isolated Pulmonary Venous Sclerosis Venous Form Of Primary Pulmonary Hypertension Pulmonary Venoocclusive Disease 1, Autosomal Dominant
Ischiocoxopodopatellar Syndrome With Or Without Pulmonary Arterial Hypertension	Small Patella Syndrome Ischiopatellar Dysplasia Coxopodopatellar Syndrome Scott-Taor Syndrome Sps Ischiocoxopodopatellar Syndrome Patella Aplasia, Coxa Vara, And Tarsal Synostosis ICPPS Congenital Coxa Vara, Patella Aplasia And Tarsal Synostosis Coxo-Podo-Patellar Syndrome Patella Aplasia, Coxa Vara, Tarsal Synostosis Coxopodipatellar Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01180	ATP13A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ATP13A3	VGNC	VGNC:38243
Rattus norvegicus	ATP13A3	RGD	RGD:1590881
Felis catus	ATP13A3	VGNC	VGNC:60017
Mus musculus	ATP13A3	MGD	MGI:2685387
Macaca mulatta	ATP13A3	VGNC	VGNC:70117
Bos taurus	ATP13A3	VGNC	VGNC:26279