2. Gene
  3. ARHGAP10 - Rho GTPase activating protein 10 Gene

ARHGAP10 - Rho GTPase activating protein 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GRAF2; PSGAP; PS-GAP

Gene ID: 79658 | Gene type: protein coding

About ARHGAP10

Cytogenetic location: 4q31.23 Genomic coordinates (GRCh38): 4:147,732,088-148,072,776 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 17.3), ovary (RPKM 10.9) and 23 other tissues.

Summary

Predicted to enable GTPase activator activity. Predicted to be involved in Cytoskeleton organization and negative regulation of apoptotic process. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

ARHGAP10 Products(1)

mRNA Protein Name
NM_024605.4 NP_078881.3 rho GTPase-activating protein 10

ARHGAP10 Protein Structure

RhoGAP

RhoGAP: RhoGAP domain (398 - 548)

SH3_9

SH3_9: Variant SH3 domain (735 - 784)

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  • 786 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 10

GTPase regulator associated with focal adhesion kinase 2

Related Diseases

Diseases Alias
Urocanase Deficiency

Encephalopathy Due To Urocanase Deficiency

Urocanate Hydratase Deficiency

Urocanic Aciduria

UROCD

High Urine Urocanic Acid Levels
Aarskog-Scott Syndrome

Aarskog Syndrome

Faciogenital Dysplasia

Faciodigitogenital Syndrome

AAS

Fgdy

X-Linked Aarskog Syndrome

Intellectual Developmental Disorder, X-Linked, Syndromic 16

Aarskog Syndrome, X-Linked

Intellectual Developmental Disorder, X-Linked Syndromic 16

Greig'S Syndrome

Aarskog Scott Syndrome

Aarskog Disease

Scott Aarskog Syndrome

Facio-Digito-Genital Dysplasia

Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder

Aarskog-Scott Syndrome ) Syndrome
Non-Syndromic X-Linked Intellectual Disability 30

Mrx30

Mrx47

X-Linked Mental Retardation 30/47

X-Linked Mental Retardation 47

Mental Retardation, X-Linked, Type 30/47
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00912 ARHGAP10 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ARHGAP10 VGNC VGNC:69914
Felis catus ARHGAP10 VGNC VGNC:59874
Rattus norvegicus ARHGAP10 RGD RGD:1588859
Canis familiaris ARHGAP10 VGNC VGNC:38045
Mus musculus ARHGAP10 MGD MGI:1925764
Bos taurus ARHGAP10 VGNC VGNC:26074