ARHGAP10 - Rho GTPase activating protein 10 Gene

Also Known as GRAF2; PSGAP; PS-GAP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79658

About ARHGAP10

Cytogenetic location: 4q31.23 Genomic coordinates (GRCh38): 4:147,732,088-148,072,776 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 17.3), ovary (RPKM 10.9) and 23 other tissues.

Summary

Predicted to enable GTPase activator activity. Predicted to be involved in Cytoskeleton organization and negative regulation of apoptotic process. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

ARHGAP10 Products (1)

mRNA Protein Name
NM_024605.4 NP_078881.3 rho GTPase-activating protein 10

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11432776 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
32344433 GOA
located in endosome membrane IDA
IDA: Inferred from direct assay
32344433 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP10 Protein Structure

RhoGAP

RhoGAP: RhoGAP domain (398 - 548)

SH3_9

SH3_9: Variant SH3 domain (735 - 784)

  • 0
  • 200
  • 400
  • 600
  • 786 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 10

  • GTPase regulator associated with focal adhesion kinase 2

Related Diseases

Diseases Alias
Urocanase Deficiency

  • Encephalopathy Due To Urocanase Deficiency

  • Urocanate Hydratase Deficiency

  • Urocanic Aciduria

  • UROCD

  • High Urine Urocanic Acid Levels
Aarskog-Scott Syndrome

  • Aarskog Syndrome

  • Faciogenital Dysplasia

  • Faciodigitogenital Syndrome

  • AAS

  • Fgdy

  • X-Linked Aarskog Syndrome

  • Intellectual Developmental Disorder, X-Linked, Syndromic 16

  • Aarskog Syndrome, X-Linked

  • Intellectual Developmental Disorder, X-Linked Syndromic 16

  • Greig'S Syndrome

  • Aarskog Scott Syndrome

  • Aarskog Disease

  • Scott Aarskog Syndrome

  • Facio-Digito-Genital Dysplasia

  • Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder

  • Aarskog-Scott Syndrome ) Syndrome
Non-Syndromic X-Linked Intellectual Disability 30

  • Mrx30

  • Mrx47

  • X-Linked Mental Retardation 30/47

  • X-Linked Mental Retardation 47

  • Mental Retardation, X-Linked, Type 30/47
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00912 ARHGAP10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00921 ARHGAP21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ARHGAP10 VGNC VGNC:69914
Felis catus ARHGAP10 VGNC VGNC:59874
Rattus norvegicus ARHGAP10 RGD RGD:1588859
Canis familiaris ARHGAP10 VGNC VGNC:38045
Mus musculus ARHGAP10 MGD MGI:1925764
Bos taurus ARHGAP10 VGNC VGNC:26074
Others ARHGAP10 NCBI