ZNF750 - zinc finger protein 750 Gene

Also Known as SLDPE; ZFP750

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79755

About ZNF750

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,829,434-82,840,022 (from NCBI)

This gene has 2 transcripts (splice variants), 202 orthologues, 2 paralogues and is associated with 3 phenotypes. Biased expression in esophagus (RPKM 37.2), skin (RPKM 25.3) and 5 other tissues.

Summary

This gene encodes a protein with a nuclear localization site and a C2H2 zinc finger domain. Mutations in this gene have been associated with seborrhea-like dermatitis with psoriasiform elements. [provided by RefSeq, Jul 2008]

ZNF750 Products (1)

mRNA Protein Name
NM_024702.3 NP_078978.2 zinc finger protein 750

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
22364861 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
32042337 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
22364861 GOA
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
27907090 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in epidermis development IMP
IMP: Inferred from mutant phenotype
22364861 GOA
involved in negative regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
32042337 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
32042337 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22364861 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
27907090 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
22364861 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF750 Protein Structure

zf-C2H2_7

zf-C2H2_7: Zinc-finger (5 - 58)

  • 0
  • 200
  • 400
  • 600
  • 723 a.a.
Protein Preferred Names Protein Names

zinc finger protein 750

  • protein ZNF750

Related Diseases

Diseases Alias
Seborrhea-Like Dermatitis With Psoriasiform Elements

  • SLDP
Dermatitis

  • Eczema

  • Skin Inflammation

  • Inflammatory Dermatosis
Seborrheic Dermatitis

  • Seborrhoeic Dermatitis

  • Seborrhea

  • Seborrhoeic Eczema

  • Skin Seborrheic

  • Dermatitis, Seborrheic
Rectosigmoid Junction Neoplasm

  • Neoplasm Of Rectosigmoid Junction

  • Rectosigmoid Neoplasm

  • Rectosigmoid Tumor

  • Rectosigmoid Carcinoma

  • Carcinoma Of The Rectosigmoid Junction

  • Malignant Tumor Of Rectosigmoid Junction

  • Rectosigmoid Junction Cancer

  • Primary Malignant Neoplasm Of Rectosigmoid Junction

  • Rectosigmoid Colon Cancer

  • Carcinoma Of Rectum With Sigmoid

  • Colorectal Cancer Nos

  • Colorectal Carcinoma Nos

  • Rectosigmoid Cancer
Squamous Cell Carcinoma

  • Epidermoid Carcinoma

  • Squamous Cell Cancer

  • Carcinoma, Squamous Cell

  • Squamous Cell Skin Cancer

  • Malignant Squamous Cell Tumor

  • Squamous Carcinoma

  • Squamous Cell Epithelioma

  • Carcinoma Squamous Cell

  • Neoplasms, Squamous Cell

  • Squamous Cell Carcinoma - Category

  • Malignant Squamous Cell Neoplasm

  • Squamous Cell Carcinoma Of Skin
Sigmoid Neoplasm

  • Sigmoid Neoplasms

  • Neoplasm Of Sigmoid Colon

  • Tumor Of Sigmoid Colon
Lung Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Lung

  • Squamous Cell Lung Carcinoma

  • Epidermoid Cell Carcinoma Of The Lung

  • Squamous Cell Lung Cancer
Eyelid Carcinoma

  • Carcinoma Of The Eyelid
Seborrheic Infantile Dermatitis

  • Cradle Cap

  • Infantile Seborrhoeic Dermatitis

  • Seborrhoea Capitis

  • Seborrhoeic Dermatitis Of Scalp

  • Seborrhoeic Eczema Of Scalp

  • Complement 5 Dysfunction

  • Generalized Seborrheic Dermatitis Of Infants

  • Infantile Seborrheic Dermatitis

  • Pityriasis Capitis

  • Seborrhea Capitis

  • Seborrhea Sicca

  • Dandruff

  • Complement Component 5 Deficiency

  • Seborrheic Dermatitis

  • Seborrheic Dermatitis Of Scalp

  • Scurfiness Of Scalp

  • Seborrheic Dermatitis Of Infancy

  • Infantile Seborrhoeic Eczema

  • Neonatal Seborrhoeic Dermatitis

  • Infantile Seborrhoeic Dermatitis Of The Scalp
Muir-Torre Syndrome

  • MRTES

  • Keratoacanthoma

  • Muir-Torré Syndrome

  • Cutaneous Sebaceous Neoplasms And Keratoacanthomas, Multiple, With Gastrointestinal And Other Carcinomas

  • Cutaneous Sebaceous Neoplasms And Keratoacanthomas Multiple With Gastrointestinal And Other Carcinomas

  • Multiple Keratoacanthoma, Muir-Torre Type

  • Mts

  • Torre-Muir Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16173 ZNF750 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZNF750 RGD RGD:1590044
Mus musculus ZNF750 MGD MGI:2442210
Felis catus ZNF750 VGNC VGNC:67354
Canis familiaris ZNF750 VGNC VGNC:48810
Bos taurus ZNF750 VGNC VGNC:37340
Macaca mulatta ZNF750 VGNC VGNC:104679
Others ZNF750 NCBI