TREML2 - triggering receptor expressed on myeloid cells like 2 Gene

Also Known as TLT2; TLT-2; C6orf76; dJ238O23.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79865

About TREML2

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,189,749-41,201,149 (from NCBI)

This gene has 1 transcript (splice variant), 105 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 5.6), lymph node (RPKM 5.1) and 6 other tissues.

Summary

TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]

TREML2 Products (1)

mRNA Protein Name
NM_024807.4 NP_079083.2 trem-like transcript 2 protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18650384 GOA
enables signaling receptor activity IDA
IDA: Inferred from direct assay
18650384 GOA
Biological Process GO Annotation Evidence References Source
involved in T cell activation IDA
IDA: Inferred from direct assay
18650384 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
18650384 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TREML2 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (28 - 114)

  • 0
  • 100
  • 200
  • 300
  • 321 a.a.
Protein Preferred Names Protein Names

trem-like transcript 2 protein

  • triggering receptor expressed on myeloid cells-like protein 2

Recombinant TREML2 Proteins

Cat. No. 상품명 Accession Purity
HY-P71383 TREML2 Protein, Human (HEK293, Fc) Q5T2D2 (G19-S268) ≥ 95%, as determined by reducing SDS-PAGE.

TREML2 Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P84635 TLT2 Antibody (YA4332) IHC-P, ICC/IF, FC, ELISA Human
HY-P84635A TLT2 Antibody (YA4332)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

  • Nasu-Hakola Disease

  • Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

  • Plosl

  • Nhd

  • Presenile Dementia With Bone Cysts

  • Plo-Sl

  • PLOSL1

  • Dementia, Prefrontal, With Bone Cysts

  • Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia

  • Brain-Bone-Fat Disease

  • Progressive Dementia With Lipomembranous Polycystic Osteodysplasia

  • Brain-Bone-Fat Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS15005 TREML2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19079 Treml2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25570 Treml2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TREML2 RGD RGD:1587039
Canis familiaris TREML2 VGNC VGNC:47795
Mus musculus TREML2 MGD MGI:2147038
Macaca mulatta TREML2 VGNC VGNC:79309
Bos taurus TREML2 VGNC VGNC:36301
Others TREML2 NCBI