country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

THSD4 - thrombospondin type 1 domain containing 4 Gene

Also Known as AAT12; ADAMTSL6; FVSY9334; PRO34005; ADAMTSL-6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79875

About THSD4

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:71,096,894-71,783,383 (from NCBI)

This gene has 7 transcripts (splice variants), 205 orthologues, 25 paralogues and is associated with 1 phenotype. Broad expression in esophagus (RPKM 9.7), prostate (RPKM 9.0) and 20 other tissues.

Summary

Predicted to enable hydrolase activity. Predicted to be an extracellular matrix structural constituent. Predicted to act upstream of or within elastic fiber assembly. Located in collagen-containing extracellular matrix and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

THSD4 Products (3)

mRNA	Protein	Name
NM_001286429.2	NP_001273358.1	thrombospondin type-1 domain-containing protein 4 isoform 2 precursor
NM_001394532.1	NP_001381461.1	thrombospondin type-1 domain-containing protein 4 isoform 1 precursor
NM_024817.3	NP_079093.2	thrombospondin type-1 domain-containing protein 4 isoform 1 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in microfibril assembly	IMP IMP: Inferred from mutant phenotype	32855533	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in microfibril	IMP IMP: Inferred from mutant phenotype	32855533	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THSD4 Protein Structure

TSP_1

ADAM_spacer1

TSP_1

PLAC

0
200
400
600
800
1018 a.a.

Protein Preferred Names	Protein Names
thrombospondin type-1 domain-containing protein 4	A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6

Related Diseases

Diseases	Alias
Aortic Aneurysm, Familial Thoracic 12	AAT12
Ectopia Lentis 1, Isolated, Autosomal Dominant	ECTOL1 Ectopia Lentis, Familial Autosomal Dominant Isolated Ectopia Lentis 1
Ectopia Lentis 2, Isolated, Autosomal Recessive	ECTOL2 Ectopia Lentis, Isolated, Autosomal Recessive Autosomal Recessive Isolated Ectopia Lentis 2 Autosomal Recessive Isolated Ectopia Lentis Ectopia Lentis, Isolated Autosomal Recessive Ectopia Lentis, Isolated Autosomal Recessive, Type 2
Isolated Ectopia Lentis	Familial Ectopia Lentis Ectopia Lentis Ectopia Lentis Syndrome Lens Subluxation Iel Congenital Ectopia Lentis Subluxation Of Lens Ectopia Lentis, Isolated Ectopia Lentis Isolated
Marfan Syndrome	MFS Mfs1 Marfan'S Syndrome Marfan Syndrome Type 1 Marfan Syndrome, Type I Mass Phenotype Contractural Arachnodactyly Mass Syndrome Octd Overlap Connective Tissue Disease Marfanoid Hypermobility Syndrome Marfan Disease
Phacolytic Glaucoma
Peters-Plus Syndrome	Krause-Kivlin Syndrome Peters Plus Syndrome Peters Anomaly Irido-Corneo-Trabecular Dysgenesis PTRPLS Peters Anomaly With Short-Limb Dwarfism Peters Anomaly-Short Limb Dwarfism Syndrome Peters Anomaly With Short Limb Dwarfism Peters Congenital Glaucoma Krause-Van Schooneveld-Kivlin Syndrome Peters' Plus Syndrome Peters'-Plus Syndrome Anomaly Peters
Weill-Marchesani Syndrome	Gemss Syndrome Spherophakia-Brachymorphia Syndrome Marchesani-Weill Syndrome Wms Congenital Mesodermal Dystrophy Mesodermal Dysmorphodystrophy, Congenital Spherophakia Brachymorphia Syndrome Mesodermal Dysmorphodystrophy Congenital Wm Syndrome Brachydactyly-Spherophakia Syndrome Brachymorphy With Spherophakia Syndrome Congenital Mesodermal Dysmorphodystrophy Marchesani Syndrome Weill-Marchesani Syndrome, Autosomal Recessive Weill-Marchesani Syndrome, Autosomal Dominant
Geleophysic Dysplasia	Geleophysic Dwarfism Gphysd
Acromicric Dysplasia	ACMICD Acromicric Skeletal Dysplasia Dysplasia, Acromicric
Winchester Syndrome	WNCHRS Winchester Disease Winchester-Grossman Syndrome
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Familial Thoracic Aortic Aneurysm Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14504	THSD4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21787	Thsd4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28303	Thsd4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	THSD4	VGNC	VGNC:80822
Mus musculus	THSD4	MGD	MGI:2672033
Canis familiaris	THSD4	VGNC	VGNC:103650
Macaca mulatta	THSD4	VGNC	VGNC:99269
Rattus norvegicus	THSD4	RGD	RGD:1566296
Others	THSD4	NCBI