BICC1 - BicC family RNA binding protein 1 Gene

Also Known as BICC; CYSRD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80114

About BICC1

Cytogenetic location: 10q21.1 Genomic coordinates (GRCh38): 10:58,512,220-58,831,435 (from NCBI)

This gene has 3 transcripts (splice variants), 216 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in kidney (RPKM 5.8), gall bladder (RPKM 2.9) and 22 other tissues.

Summary

This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product. [provided by RefSeq, Apr 2009]

BICC1 Products (1)

mRNA Protein Name
NM_001080512.3 NP_001073981.1 protein bicaudal C homolog 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
21922595 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BICC1 Protein Structure

KH_1

KH_1: KH domain (134 - 199)

KH_1

KH_1: KH domain (288 - 347)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (878 - 933)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 974 a.a.
Protein Preferred Names Protein Names

protein bicaudal C homolog 1

  • FGFR2-BICC1 fusion kinase protein

Related Diseases

Diseases Alias
Renal Dysplasia, Cystic

  • CYSRD

  • Renal Dysplasia, Cystic, Susceptibility To

  • Diffuse Cystic Renal Dysplasia

  • Renal Dysplasia Diffuse Cystic

  • Cystic Renal Dysplasia

  • Susceptibility To Cystic Renal Dysplasia

  • Dysplasia, Renal, Cystic, Susceptibility To

  • Multicystic Dysplastic Kidney
Renal Hypodysplasia/Aplasia 1

  • Renal Agenesis

  • Renal Adysplasia

  • Renal Aplasia

  • RHDA1

  • Hereditary Renal Aplasia

  • Hra

  • Hereditary Urogenital Adysplasia

  • Hypodysplasia/Aplasia, Renal, Type 1

  • Congenital Absence Of Kidneys Syndrome

  • Congenital Absence Of Kidney

  • Aplastic Kidney
Autosomal Dominant Polycystic Kidney Disease

  • Polycystic Kidney Disease, Adult Type

  • Adpkd

  • Polycystic Kidney Diseases

  • Polycystic Kidney, Autosomal Dominant

  • Congenital Biliary Ectasias

  • Polycystic Kidney And Hepatic Disease 1

  • Polycystic Kidney Disease, Autosomal Dominant

  • Kidney, Polycystic, Disease, Autosomal Dominant

  • Adult Polycystic Kidney Disease

  • Polycystic Kidney, Adult Type

  • Apckd - [Autosomal Polycystic Kidney Disease]
Spermatogenic Failure 6

  • Globozoospermia

  • SPGF6

  • Round-Headed Spermatozoa

  • Acrosome Malformation Of Spermatozoa

  • Spermatogenic Failure 9

  • Spermatozoa, Round-Headed

  • Globozoospermia, Complete

  • Globozoospermia, Total

  • Mae Infertility Due To Round-Headed Spermatozoa

  • Male Infertility Due To Globozoospermia

  • Male Infertility Due To Round-Headed Spermatozoa

  • Round-Headed Sperm Syndrome

  • Spgf9

  • Teratozoospermia
Astigmatism
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease

  • Polycystic Kidney Disease 2

  • PKD2

  • Polycystic Kidney Disease, Adult, Type Ii

  • Apkd2

  • Polycystic Kidney Disease, Type 2

  • Adpkd2

  • Adult Polycystic Kidney Disease Type 2

  • Autosomal Dominant Polycystic Kidney Disease 2

  • Pkd-2

  • Polycystic Kidney Disease Adult Type Ii

  • Polycystic Kidney Type 2 Autosomal Dominant Disease

  • Kidney Disease, Polycystic, Type 2
Myopia

  • Near-Sightedness

  • Short-Sightedness

  • Nearsightedness

  • Nearsighted

  • Near Vision

  • Close Sighted

  • Myopic

  • Short-Sighted

  • Near Sighted
Intrahepatic Cholangiocarcinoma

  • Cholangiocarcinoma

  • Intrahepatic Bile Duct Carcinoma

  • Peripheral Cholangiocarcinoma

  • Peripheral Intrahepatic Cholangiocarcinoma

  • Adenocarcinoma Of Intra-Hepatic Bile Ducts

  • Cholangiocarcinoma, Unspecified Site

  • Cholangiocarcinoma Of Liver
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

  • Polycystic Kidney Disease 1

  • PKD1

  • Adpkd

  • Polycystic Kidney Disease, Adult, Type I

  • Apkd1

  • Potter Type Iii Polycystic Kidney Disease

  • Polycystic Kidney Disease, Adult

  • Potter Type Iii Polycystic Kidney Disease, Formerly

  • Polycystic Kidney Disease, Type 1

  • Adpkd1

  • Adult Polycystic Kidney Disease Type 1

  • Autosomal Dominant Polycystic Kidney Disease 1

  • Pkd-1

  • Polycystic Kidney Disease Adult

  • Polycystic Kidney Disease Type I

  • Polycystic Kidneys

  • Polycystic Kidney Disease, Adult Type I

  • Polycystic Kidney Type 1 Autosomal Dominant Disease

  • Kidney Disease, Polycystic, Type 1

  • Polycystic Kidney, Autosomal Dominant

  • Polycystic Kidney, Type 1 Autosomal Dominant Disease

  • Polycystic Kidney Diseases
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease

  • Autosomal Recessive Polycystic Kidney Disease

  • Arpkd

  • Polycystic Kidney Disease, Autosomal Recessive

  • Polycystic Kidney And Hepatic Disease 1

  • Pkhd1

  • PKD4

  • Polycystic Kidney Disease 4 With Or Without Hepatic Disease

  • Polycystic Kidney Disease, Infantile, Type I

  • Polycystic Kidney Disease, Infantile Type

  • Polycystic Kidney, Autosomal Recessive

  • Pkd3, Formerly

  • Polycystic Kidney Disease 4, With Or Without Hepatic Disease

  • Arpkd/Chf

  • Ar-Pkd

  • Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease

  • Infantile Polycystic Kidney Disease Type I

  • Pkd3

  • Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease

  • Polycystic Kidney Disease 3, Autosomal Dominant
Cystic Kidney Disease

  • Renal Cyst

  • Simple Renal Cyst

  • Kidney Cysts

  • Kidney Diseases, Cystic

  • Renal Cysts

  • Kidney Cyst

  • Cystic Kidney

  • Congenital Cystic Kidney Disease

  • Cystic Kidney Diseases

  • Bosniak 1 Cyst
Polycystic Kidney Disease

  • Polycystic Kidney Diseases

  • Pkd

  • Polycystic Renal Disease

  • Kidney Disease, Polycystic

  • Polycystic Kidney, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01497 BICC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21499 Bicc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28017 Bicc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris BICC1 VGNC VGNC:38449
Mus musculus BICC1 MGD MGI:1933388
Felis catus BICC1 VGNC VGNC:60111
Bos taurus BICC1 VGNC VGNC:26490
Rattus norvegicus BICC1 RGD RGD:1307459
Macaca mulatta BICC1 VGNC VGNC:70348
Others BICC1 NCBI