IFT74 - intraflagellar transport 74 Gene

Also Known as CMG1; BBS22; CCDC2; CMG-1; JBTS40; SPGF58

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 80173

Summary

This gene encodes a core intraflagellar transport (IFT) protein which belongs to a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT proteins are found at the base of the cilium as well as inside the cilium, where they assemble into long arrays between the ciliary base and tip. This protein, together with intraflagellar transport protein 81, binds and transports tubulin within cilia and is required for ciliogenesis. Naturally occurring mutations in this gene are associated with amyotrophic lateral sclerosis--frontotemporal dementia and Bardet-Biedl Syndrome. [provided by RefSeq, Mar 2017]

IFT74 Products (1)

mRNA Protein Name
NM_001099224.3 NP_001092694.1 intraflagellar transport protein 74 homolog isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-tubulin binding IDA
IDA: Inferred from direct assay
23990561 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28428259 GOA
Biological Process GO Annotation Evidence References Source
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
23990561 GOA
involved in intraciliary transport involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
23990561 GOA
Cellular Component GO Annotation Evidence References Source
part of intraciliary transport particle B IPI
IPI: Inferred from physical interaction
26980730 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

intraflagellar transport protein 74 homolog

  • capillary morphogenesis gene 1 protein

  • capillary morphogenesis protein 1

  • coiled-coil domain containing 2

  • coiled-coil domain-containing protein 2

  • intraflagellar transport 74 homolog