Sptbn4 - spectrin beta, non-erythrocytic 4 Gene

Also Known as qv; dyn; lnd; SpbIV; Spnb4; ROSA62; nmf261; nmf379; 1700022P15Rik; 5830426A08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 80297

Summary

Enables actin binding activity; ankyrin binding activity; and spectrin binding activity. Involved in clustering of voltage-gated sodium channels and protein localization to plasma membrane. Acts upstream of or within several processes, including adult walking behavior; regulation of heart contraction; and regulation of peptidyl-serine phosphorylation. Located in several cellular components, including axon; cell body fiber; and intercalated disc. Colocalizes with adherens junction. Is expressed in several structures, including liver; neural ectoderm; optic vesicle; spinal cord lateral wall; and spleen. Orthologous to human SPTBN4 (spectrin beta, non-erythrocytic 4). [provided by Alliance of Genome Resources, Apr 2022]

Sptbn4 Products (4)

mRNA Protein Name
NM_001199234.1 NP_001186163.1 spectrin beta chain, non-erythrocytic 4 isoform sigma6
NM_001199235.1 NP_001186164.1 spectrin beta chain, non-erythrocytic 4 isoform sigma6
NM_001199236.1 NP_001186165.1 spectrin beta chain, non-erythrocytic 4 isoform sigma6
NM_032610.2 NP_115999.2 spectrin beta chain, non-erythrocytic 4 isoform sigma1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
20877009 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20877009 MGI
enables spectrin binding IDA
IDA: Inferred from direct assay
20877009 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adult behavior IMP
IMP: Inferred from mutant phenotype
1634998 MGI
acts upstream of or within adult walking behavior IMP
IMP: Inferred from mutant phenotype
1634998 MGI
acts upstream of or within axonogenesis IMP
IMP: Inferred from mutant phenotype
1634998 MGI
acts upstream of or within cardiac conduction IMP
IMP: Inferred from mutant phenotype
20877009 MGI
acts upstream of or within central nervous system projection neuron axonogenesis IMP
IMP: Inferred from mutant phenotype
17197442 MGI
acts upstream of or within clustering of voltage-gated sodium channels IMP
IMP: Inferred from mutant phenotype
17197442 MGI
acts upstream of or within fertilization IMP
IMP: Inferred from mutant phenotype
1634998 MGI
acts upstream of or within negative regulation of heart rate IMP
IMP: Inferred from mutant phenotype
20877009 MGI
acts upstream of or within neuromuscular junction development IMP
IMP: Inferred from mutant phenotype
20962009 MGI
acts upstream of or within neuromuscular process IMP
IMP: Inferred from mutant phenotype
20962009 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
1634998 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
20877009 MGI
involved in protein localization IMP
IMP: Inferred from mutant phenotype
16687515 MGI
acts upstream of or within protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
20962009 MGI
acts upstream of or within protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
20962009 MGI
acts upstream of or within regulation of peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
20877009 MGI
acts upstream of or within regulation of sodium ion transport IMP
IMP: Inferred from mutant phenotype
20877009 MGI
acts upstream of or within reproductive process IMP
IMP: Inferred from mutant phenotype
17197442 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
15381686 MGI
acts upstream of or within transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
15381686 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
15381686 MGI
located in axon hillock IDA
IDA: Inferred from direct assay
15381686 MGI
located in axon initial segment IDA
IDA: Inferred from direct assay
20877009 MGI
located in cell body fiber IDA
IDA: Inferred from direct assay
18796539 MGI
located in intercalated disc IDA
IDA: Inferred from direct assay
26187182 MGI
is active in juxtaparanode region of axon IMP
IMP: Inferred from mutant phenotype
20962009 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
20877009 MGI
is active in node of Ranvier IMP
IMP: Inferred from mutant phenotype
16687515 MGI
located in paranode region of axon IDA
IDA: Inferred from direct assay
20188654 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

spectrin beta chain, non-erythrocytic 4

  • beta-spectrin 4

  • lumbosacral neuroaxonal dystrophy

  • neuroaxonal dystrophy

  • quivering

  • spectrin beta 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13734 SPTBN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sptbn4 NCBI NCBI:57731