Tusc2 - tumor suppressor 2, mitochondrial calcium regulator Gene

Also Known as PAP; Fus1; Lgcc; Pdap2; 1190001E22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 80385

Summary

Acts upstream of or within several processes, including natural killer cell differentiation; neutrophil-mediated killing of gram-negative bacterium; and regulation of cytokine production. Located in mitochondrion. Is expressed in liver and metanephros. Orthologous to human TUSC2 (tumor suppressor 2, mitochondrial calcium regulator). [provided by Alliance of Genome Resources, Apr 2022]

Tusc2 Products (1)

mRNA Protein Name
NM_019742.4 NP_062716.1 tumor suppressor candidate 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell maturation IGI
IGI: Inferred from genetic interaction
17318811 MGI
acts upstream of or within cell maturation IMP
IMP: Inferred from mutant phenotype
17318811 MGI
acts upstream of or within chemokine (C-C motif) ligand 5 production IMP
IMP: Inferred from mutant phenotype
22513871 MGI
acts upstream of or within defense response to Gram-negative bacterium IMP
IMP: Inferred from mutant phenotype
24042119 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
22513871 MGI
acts upstream of or within interleukin-15 production IMP
IMP: Inferred from mutant phenotype
17318811 MGI
acts upstream of or within natural killer cell differentiation IGI
IGI: Inferred from genetic interaction
17318811 MGI
acts upstream of or within natural killer cell differentiation IMP
IMP: Inferred from mutant phenotype
17318811 MGI
acts upstream of or within negative regulation of interleukin-17 production IMP
IMP: Inferred from mutant phenotype
24042119 MGI
acts upstream of or within neutrophil-mediated killing of gram-negative bacterium IMP
IMP: Inferred from mutant phenotype
24042119 MGI
acts upstream of or within phagocytosis IMP
IMP: Inferred from mutant phenotype
24042119 MGI
acts upstream of or within positive regulation of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
24042119 MGI
acts upstream of or within regulation of mitochondrial membrane potential IMP
IMP: Inferred from mutant phenotype
22513871 MGI
acts upstream of or within regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
22513871 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
17318811 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor suppressor candidate 2

  • PDGFA associated protein 2

  • fus-1 protein

  • fusion 1 protein

  • lung cancer candidiate, FUS

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15274 TUSC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tusc2 NCBI NCBI:11334