Tusc2 - tumor suppressor 2, mitochondrial calcium regulator Gene

Mus musculus

Also known as PAP; Fus1; Lgcc; Pdap2; 1190001E22Rik

Gene ID: 80385 | Gene type: protein coding

About Tusc2

Summary

Acts upstream of or within several processes, including natural killer cell differentiation; neutrophil-mediated killing of gram-negative bacterium; and regulation of cytokine production. Located in mitochondrion. Is expressed in liver and metanephros. Orthologous to human TUSC2 (tumor suppressor 2, mitochondrial calcium regulator). [provided by Alliance of Genome Resources, Apr 2022]

Tusc2 Products(1)

mRNA	Protein	Name
NM_019742.4	NP_062716.1	tumor suppressor candidate 2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell maturation	IGI IGI: Inferred from genetic interaction	17318811	MGI
acts upstream of or within cell maturation	IMP IMP: Inferred from mutant phenotype	17318811	MGI
acts upstream of or within chemokine (C-C motif) ligand 5 production	IMP IMP: Inferred from mutant phenotype	22513871	MGI
acts upstream of or within defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	24042119	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	22513871	MGI
acts upstream of or within interleukin-15 production	IMP IMP: Inferred from mutant phenotype	17318811	MGI
acts upstream of or within natural killer cell differentiation	IGI IGI: Inferred from genetic interaction	17318811	MGI
acts upstream of or within natural killer cell differentiation	IMP IMP: Inferred from mutant phenotype	17318811	MGI
acts upstream of or within negative regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	24042119	MGI
acts upstream of or within neutrophil-mediated killing of gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	24042119	MGI
acts upstream of or within phagocytosis	IMP IMP: Inferred from mutant phenotype	24042119	MGI
acts upstream of or within positive regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	24042119	MGI
acts upstream of or within regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	22513871	MGI
acts upstream of or within regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	22513871	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	17318811	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tumor suppressor candidate 2

PDGFA associated protein 2	fus-1 protein
fusion 1 protein	lung cancer candidiate, FUS

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15274	TUSC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tusc2	NCBI	NCBI:11334

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