Wwox - WW domain-containing oxidoreductase Gene

Mus musculus

Also known as WOX1; 5330426P09Rik; 9030416C10Rik

Gene ID: 80707 | Gene type: protein coding

About Wwox

Summary

Enables enzyme binding activity. Contributes to transcription coactivator activity. Involved in cellular response to transforming growth factor beta stimulus; positive regulation of extrinsic apoptotic signaling pathway; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including apoptotic signaling pathway; osteoblast differentiation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in mitochondrion and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; head mesenchyme derived from neural crest; musculoskeletal system; sensory organ; and spinal ganglion. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase). [provided by Alliance of Genome Resources, Apr 2022]

Wwox Products(1)

mRNA	Protein	Name
NM_019573.3	NP_062519.2	WW domain-containing oxidoreductase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	19366691	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11058590	MGI
contributes to transcription coactivator activity	IDA IDA: Inferred from direct assay	19366691	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	19366691	MGI
acts upstream of or within extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	19366691	MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator	IGI IGI: Inferred from genetic interaction	11058590	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	18487609	MGI
involved in positive regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	19366691	MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	19366691	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19366691	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	18487609	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	19366691	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	11058590	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11058590	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

WW domain-containing oxidoreductase

WW-domain oxidoreductase

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15859	WWOX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wwox	NCBI	NCBI:51741

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