Pacsin3 - protein kinase C and casein kinase substrate in neurons 3 Gene

Mus musculus

Also known as 4921507A02Rik; 6330413E15Rik

Gene ID: 80708 | Gene type: protein coding

About Pacsin3

Summary

Enables Calcium Channel Inhibitor activity; cytoskeletal protein binding activity; and lipid binding activity. Involved in negative regulation of calcium ion transport and plasma membrane tubulation. Acts upstream of or within negative regulation of endocytosis. Located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human PACSIN3 (protein kinase C and Casein Kinase substrate in neurons 3). [provided by Alliance of Genome Resources, Apr 2022]

Pacsin3 Products(4)

mRNA	Protein	Name
NM_001289677.1	NP_001276606.1	protein kinase C and casein kinase II substrate protein 3
NM_001289678.1	NP_001276607.1	protein kinase C and casein kinase II substrate protein 3
NM_028733.4	NP_083009.1	protein kinase C and casein kinase II substrate protein 3
NM_030880.3	NP_112019.2	protein kinase C and casein kinase II substrate protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel inhibitor activity	IMP IMP: Inferred from mutant phenotype	18174177	MGI
enables cytoskeletal protein binding	IDA IDA: Inferred from direct assay	11082044	MGI
enables lipid binding	IDA IDA: Inferred from direct assay	22573331	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11082044	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	18174177	MGI
acts upstream of or within negative regulation of endocytosis	IDA IDA: Inferred from direct assay	11082044	MGI
involved in negative regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	16627472	MGI
involved in plasma membrane tubulation	IDA IDA: Inferred from direct assay	22573331	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11082044	MGI
NOT located in trans-Golgi network	IDA IDA: Inferred from direct assay	11082044	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein kinase C and casein kinase II substrate protein 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09959	PACSIN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pacsin3	NCBI	NCBI:29763

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