TTYH3 - tweety family member 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80727

About TTYH3

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:2,631,986-2,664,802 (from NCBI)

This gene has 7 transcripts (splice variants), 268 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 20.5), kidney (RPKM 16.0) and 24 other tissues.

Summary

This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel. [provided by RefSeq, Jul 2008]

TTYH3 Products (1)

mRNA Protein Name
NM_025250.3 NP_079526.1 protein tweety homolog 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables chloride channel activity IDA
IDA: Inferred from direct assay
34385445 GOA
enables chloride channel activity IMP
IMP: Inferred from mutant phenotype
15010458 GOA
enables intracellularly calcium-gated chloride channel activity IDA
IDA: Inferred from direct assay
16219661 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18577513 GOA
NOT enables volume-sensitive anion channel activity IDA
IDA: Inferred from direct assay
34385445 GOA
Biological Process GO Annotation Evidence References Source
involved in chloride transport IDA
IDA: Inferred from direct assay
16219661 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
15010458 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTYH3 Protein Structure

Tweety

Tweety: Tweety (25 - 425)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 523 a.a.
Protein Preferred Names Protein Names

protein tweety homolog 3

  • hTTY3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15243 TTYH3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TTYH3 VGNC VGNC:79349
Bos taurus TTYH3 VGNC VGNC:36502
Rattus norvegicus TTYH3 RGD RGD:1309549
Mus musculus TTYH3 MGD MGI:1925589
Felis catus TTYH3 VGNC VGNC:66695
Canis familiaris TTYH3 VGNC VGNC:47985
Others TTYH3 NCBI