2. Gene
  3. ITIH5 - inter-alpha-trypsin inhibitor heavy chain 5 Gene

ITIH5 - inter-alpha-trypsin inhibitor heavy chain 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as ITI-HC5; PP14776

Gene ID: 80760 | Gene type: protein coding

About ITIH5

Cytogenetic location: 10p14 Genomic coordinates (GRCh38): 10:7,559,270-7,666,966 (from NCBI)

This gene has 9 transcripts (splice variants), 212 orthologues and 11 paralogues. Broad expression in fat (RPKM 49.7), placenta (RPKM 32.8) and 18 other tissues.

Summary

This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine Protease Inhibitors and are composed of a LIGHT chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

ITIH5 Products(3)

mRNA Protein Name
NM_001001851.3 NP_001001851.1 inter-alpha-trypsin inhibitor heavy chain H5 isoform 3 precursor
NM_030569.7 NP_085046.5 inter-alpha-trypsin inhibitor heavy chain H5 isoform 1 precursor
NM_032817.6 NP_116206.4 inter-alpha-trypsin inhibitor heavy chain H5 isoform 2

ITIH5 Protein Structure

VIT

VIT: Vault protein inter-alpha-trypsin domain (48 - 161)

VWA

VWA: von Willebrand factor type A domain (295 - 456)

ITI_HC_C

ITI_HC_C: Inter-alpha-trypsin inhibitor heavy chain C-terminus (715 - 909)

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  • 956 a.a.
Protein Preferred Names Protein Names

inter-alpha-trypsin inhibitor heavy chain H5

ITI heavy chain H5

Recombinant ITIH5 Proteins

Cat. No. Product Name Accession Purity
HY-P71586 ITIH5 Protein, Human (His-SUMO) Q86UX2 (35V-161E) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06978 ITIH5 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ITIH5 MGD MGI:1925751
Canis familiaris ITIH5 VGNC VGNC:42148
Rattus norvegicus ITIH5 RGD RGD:1591485
Macaca mulatta ITIH5 VGNC VGNC:73636
Bos taurus ITIH5 VGNC VGNC:30337
Felis catus ITIH5 VGNC VGNC:62985
Others ITIH5 NCBI