STARD5 - StAR related lipid transfer domain containing 5 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80765

About STARD5

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:81,309,053-81,324,141 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 5 paralogues. Ubiquitous expression in skin (RPKM 22.1), spleen (RPKM 14.8) and 23 other tissues.

Summary

Proteins containing a steroidogenic acute regulatory-related lipid transfer (START) domain are often involved in the trafficking of lipids and Cholesterol between diverse intracellular membranes. This gene is a member of the StarD subfamily that encodes START-related lipid transfer proteins. The protein encoded by this gene is a Cholesterol transporter and is also able to bind and transport Other sterol-derived molecules related to the Cholesterol/bile acid biosynthetic pathways such as 25-hydroxycholesterol. Its expression is upregulated during endoplasmic reticulum (ER) stress. The protein is thought to act as a cytosolic sterol transporter that moves Cholesterol between intracellular membranes such as from the cytoplasm to the ER and from the ER to the Golgi apparatus. Alternative splicing of this gene produces multiple transcript variants. [provided by RefSeq, Jan 2016]

STARD5 Products (1)

mRNA Protein Name
NM_181900.3 NP_871629.1 stAR-related lipid transfer protein 5

STARD5 Protein Structure

START

START: START domain (9 - 211)

  • 0
  • 100
  • 200
  • 213 a.a.
Protein Preferred Names Protein Names

stAR-related lipid transfer protein 5

  • START domain containing 5

Related Diseases

Diseases Alias
Blount'S Disease

  • Blount Disease

  • Tibia Vara

  • Osteochondrosis Deformans Tibiae

  • Osteochondrosis Deformans Tibiae, Familial Infantile Type

  • Familial Infantile Type Osteochondrosis Deformans Tibiae

  • Blount-Barber Syndrome

  • Erlacher-Blount Syndrome

  • Infantile Tibia Vara

  • Tibia Vara Blount

  • Blount Disease, Infantile
Lipoid Congenital Adrenal Hyperplasia

  • Congenital Adrenal Hyperplasia

  • Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency

  • Congenital Lipoid Adrenal Hyperplasia

  • Lipoid Cah

  • Lipoid Adrenal Hyperplasia

  • Adrenal Hyperplasia 1

  • Cah

  • Clah

  • LCAH

  • Adrenal Hyperplasia I

  • Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism

  • Congenital Adrenal Hyperplasia Lipoid

  • Adrenal Hyperplasia, Congenital

  • Congenital Adrenal Hyperplasia, Lipoid

  • AH1

  • Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism

  • Adrenal Hyperplasia Congenital

  • Hyperplasia, Adrenal, Lipoid, Congenital

  • Congenital Adrenogenital Disorders Associated With Enzyme Deficiency

  • Congenital Adrenal Cortical Hyperplasia

  • Congenital Adrenal Gland Hyperplasia

  • Congenital Adrenogenital Syndrome

  • Congenital Hyperadrenocorticism

  • Congenital Adrenogenitalism

  • Congenital Female Adrenal Pseudohermaphroditism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13881 STARD5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus STARD5 MGD MGI:2156765
Macaca mulatta STARD5 VGNC VGNC:77949
Felis catus STARD5 VGNC VGNC:65755
Rattus norvegicus STARD5 RGD RGD:1561783
Canis familiaris STARD5 VGNC VGNC:46885
Bos taurus STARD5 VGNC VGNC:35366