APOL4 - apolipoprotein L4 Gene

Also Known as APOLIV; APOL-IV

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80832

About APOL4

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:36,189,128-36,204,833 (from NCBI)

This gene has 13 transcripts (splice variants), 514 orthologues, 6 paralogues and is associated with 1 phenotype. Broad expression in prostate (RPKM 5.7), lung (RPKM 5.4) and 24 other tissues.

Summary

This gene encodes a member of the Apolipoprotein L family. The encoded protein may play a role in lipid exchange and transport throughout the body, as well as in reverse Cholesterol transport from peripheral cells to the liver. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2020]

APOL4 Products (4)

mRNA	Protein	Name
NM_001386885.1	NP_001373814.1	apolipoprotein L4 isoform 1
NM_030643.4	NP_085146.2	apolipoprotein L4 isoform 1
NM_145660.2	NP_663693.1	apolipoprotein L4 isoform 2 precursor
NM_145661.2	NP_663694.1	apolipoprotein L4 isoform 3

APOL4 Protein Structure

ApoL

0
100
200
300
350 a.a.

Protein Preferred Names	Protein Names
apolipoprotein L4	apolipoprotein L, 4

Related Diseases

Diseases	Alias
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Congenital Muscular Dystrophy-Dystroglycanopathy Type A6	Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies Type A6 Mddga6 Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease, Large-Related Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies, Type A6
Bardet-Biedl Syndrome 2	BBS2 Bardet-Biedl Syndrome Bardet-Biedl Syndrome, Type 2 Bbs
Sleeping Sickness	African Trypanosomiasis African Sleeping Sickness Trypanosomiasis, Human East-African Trypanosomiasis, East African Trypanosomiasis African Trypanosomiasis, African Human African Trypanosomiasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00856	APOL4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	APOL4	RGD	RGD:1562332
Mus musculus	APOL4	MGD	MGI:2444921