APOL4 - apolipoprotein L4 Gene

Homo sapiens

Also known as APOLIV; APOL-IV

Gene ID: 80832 | Gene type: protein coding

About APOL4

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:36,189,128-36,204,833 (from NCBI)

This gene has 13 transcripts (splice variants), 514 orthologues, 6 paralogues and is associated with 1 phenotype. Broad expression in prostate (RPKM 5.7), lung (RPKM 5.4) and 24 other tissues.

Summary

This gene encodes a member of the apolipoprotein L family. The encoded protein may play a role in lipid exchange and transport throughout the body, as well as in reverse Cholesterol transport from peripheral cells to the liver. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2020]

APOL4 Products(4)

mRNA	Protein	Name
NM_001386885.1	NP_001373814.1	apolipoprotein L4 isoform 1
NM_030643.4	NP_085146.2	apolipoprotein L4 isoform 1
NM_145660.2	NP_663693.1	apolipoprotein L4 isoform 2 precursor
NM_145661.2	NP_663694.1	apolipoprotein L4 isoform 3

APOL4 Protein Structure

ApoL

0
100
200
300
350 a.a.

Protein Preferred Names

Protein Names

apolipoprotein L4

apolipoprotein L, 4

Related Diseases

Diseases

Alias

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Congenital Muscular Dystrophy-Dystroglycanopathy Type A6

Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies Type A6	Mddga6
Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease, Large-Related	Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies, Type A6

Bardet-Biedl Syndrome 2

BBS2	Bardet-Biedl Syndrome
Bardet-Biedl Syndrome, Type 2	Bbs

Sleeping Sickness

African Trypanosomiasis	African Sleeping Sickness
Trypanosomiasis, Human East-African	Trypanosomiasis, East African
Trypanosomiasis African	Trypanosomiasis, African
Human African Trypanosomiasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00856	APOL4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	APOL4	RGD	RGD:1562332
Mus musculus	APOL4	MGD	MGI:2444921

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