APOL3 - apolipoprotein L3 Gene

Also Known as CG121; CG12_1; APOLIII; apoL-III

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80833

About APOL3

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:36,140,323-36,166,177 (from NCBI)

This gene has 22 transcripts (splice variants), 509 orthologues and 6 paralogues. Broad expression in spleen (RPKM 16.1), fat (RPKM 13.1) and 24 other tissues.

Summary

This gene is a member of the Apolipoprotein L gene family, and it is present in a cluster with Other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including Cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

APOL3 Products (28)

mRNA Protein Name
NM_001393587.1 NP_001380516.1 apolipoprotein L3 isoform 4
NM_001393588.1 NP_001380517.1 apolipoprotein L3 isoform 4
NM_001393589.1 NP_001380518.1 apolipoprotein L3 isoform 4
NM_001393590.1 NP_001380519.1 apolipoprotein L3 isoform 4
NM_001393591.1 NP_001380520.1 apolipoprotein L3 isoform 4
NM_001393592.1 NP_001380521.1 apolipoprotein L3 isoform 4
NM_001393593.1 NP_001380522.1 apolipoprotein L3 isoform 2
NM_001393595.1 NP_001380524.1 apolipoprotein L3 isoform 2
NM_001393596.1 NP_001380525.1 apolipoprotein L3 isoform 2
NM_001393597.1 NP_001380526.1 apolipoprotein L3 isoform 2
NM_001393598.1 NP_001380527.1 apolipoprotein L3 isoform 2
NM_001393599.1 NP_001380528.1 apolipoprotein L3 isoform 2
NM_001393600.1 NP_001380529.1 apolipoprotein L3 isoform 2
NM_001393601.1 NP_001380530.1 apolipoprotein L3 isoform 2
NM_001393602.1 NP_001380531.1 apolipoprotein L3 isoform 2
NM_001393603.1 NP_001380532.1 apolipoprotein L3 isoform 2
NM_001393604.1 NP_001380533.1 apolipoprotein L3 isoform 2
NM_001393605.1 NP_001380534.1 apolipoprotein L3 isoform 5
NM_001393606.1 NP_001380535.1 apolipoprotein L3 isoform 3
NM_001393607.1 NP_001380536.1 apolipoprotein L3 isoform 3
NM_001393608.1 NP_001380537.1 apolipoprotein L3 isoform 3
NM_001393609.1 NP_001380538.1 apolipoprotein L3 isoform 3
NM_014349.3 NP_055164.1 apolipoprotein L3 isoform 2
NM_030644.2 NP_085147.1 apolipoprotein L3 isoform 2
NM_145639.2 NP_663614.1 apolipoprotein L3 isoform 2
NM_145640.2 NP_663615.1 apolipoprotein L3 isoform 1
NM_145641.3 NP_663616.1 apolipoprotein L3 isoform 3
NM_145642.3 NP_663617.1 apolipoprotein L3 isoform 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOL3 Protein Structure

ApoL

ApoL: Apolipoprotein L (91 - 396)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
Protein Preferred Names Protein Names

apolipoprotein L3

  • TNF-inducible protein CG12-1

Related Diseases

Diseases Alias
Cone-Rod Dystrophy, X-Linked, 3

  • CORDX3

  • X-Linked Cone-Rod Dystrophy 3

  • Cone-Rod Dystrophy X-Linked 3

  • Cone-Rod Dystrophy, X-Linked 3

  • Dystrophy, Cone-Rod, X-Linked, Type 3
Aland Island Eye Disease

  • AIED

  • Forsius-Eriksson Type Ocular Albinism

  • Forsius-Eriksson Syndrome

  • Autoimmune Inner Ear Disease

  • Forsius Eriksson Type Ocular Albinism

  • Aland Islands Eye Disease

  • Aaland Island Eye Disease

  • Ocular Albinism, Type Ii
Sleeping Sickness

  • African Trypanosomiasis

  • African Sleeping Sickness

  • Trypanosomiasis, Human East-African

  • Trypanosomiasis, East African

  • Trypanosomiasis African

  • Trypanosomiasis, African

  • Human African Trypanosomiasis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00854 APOL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00855 APOL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus APOL3 MGD MGI:2444921
Rattus norvegicus APOL3 RGD RGD:1306480
Others APOL3 NCBI