2. Gene
  3. APOL3 - apolipoprotein L3 Gene

APOL3 - apolipoprotein L3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CG121; CG12_1; APOLIII; apoL-III

Gene ID: 80833 | Gene type: protein coding

About APOL3

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:36,140,323-36,166,177 (from NCBI)

This gene has 22 transcripts (splice variants), 509 orthologues and 6 paralogues. Broad expression in spleen (RPKM 16.1), fat (RPKM 13.1) and 24 other tissues.

Summary

This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including Cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

APOL3 Products(28)

mRNA Protein Name
NM_001393587.1 NP_001380516.1 apolipoprotein L3 isoform 4
NM_001393588.1 NP_001380517.1 apolipoprotein L3 isoform 4
NM_001393589.1 NP_001380518.1 apolipoprotein L3 isoform 4
NM_001393590.1 NP_001380519.1 apolipoprotein L3 isoform 4
NM_001393591.1 NP_001380520.1 apolipoprotein L3 isoform 4
NM_001393592.1 NP_001380521.1 apolipoprotein L3 isoform 4
NM_001393593.1 NP_001380522.1 apolipoprotein L3 isoform 2
NM_001393595.1 NP_001380524.1 apolipoprotein L3 isoform 2
NM_001393596.1 NP_001380525.1 apolipoprotein L3 isoform 2
NM_001393597.1 NP_001380526.1 apolipoprotein L3 isoform 2
NM_001393598.1 NP_001380527.1 apolipoprotein L3 isoform 2
NM_001393599.1 NP_001380528.1 apolipoprotein L3 isoform 2
NM_001393600.1 NP_001380529.1 apolipoprotein L3 isoform 2
NM_001393601.1 NP_001380530.1 apolipoprotein L3 isoform 2
NM_001393602.1 NP_001380531.1 apolipoprotein L3 isoform 2
NM_001393603.1 NP_001380532.1 apolipoprotein L3 isoform 2
NM_001393604.1 NP_001380533.1 apolipoprotein L3 isoform 2
NM_001393605.1 NP_001380534.1 apolipoprotein L3 isoform 5
NM_001393606.1 NP_001380535.1 apolipoprotein L3 isoform 3
NM_001393607.1 NP_001380536.1 apolipoprotein L3 isoform 3
NM_001393608.1 NP_001380537.1 apolipoprotein L3 isoform 3
NM_001393609.1 NP_001380538.1 apolipoprotein L3 isoform 3
NM_014349.3 NP_055164.1 apolipoprotein L3 isoform 2
NM_030644.2 NP_085147.1 apolipoprotein L3 isoform 2
NM_145639.2 NP_663614.1 apolipoprotein L3 isoform 2
NM_145640.2 NP_663615.1 apolipoprotein L3 isoform 1
NM_145641.3 NP_663616.1 apolipoprotein L3 isoform 3
NM_145642.3 NP_663617.1 apolipoprotein L3 isoform 3

APOL3 Protein Structure

ApoL

ApoL: Apolipoprotein L (91 - 396)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
Protein Preferred Names Protein Names

apolipoprotein L3

TNF-inducible protein CG12-1

Related Diseases

Diseases Alias
Cone-Rod Dystrophy, X-Linked, 3

CORDX3

X-Linked Cone-Rod Dystrophy 3

Cone-Rod Dystrophy X-Linked 3

Cone-Rod Dystrophy, X-Linked 3

Dystrophy, Cone-Rod, X-Linked, Type 3
Aland Island Eye Disease

AIED

Forsius-Eriksson Type Ocular Albinism

Forsius-Eriksson Syndrome

Autoimmune Inner Ear Disease

Forsius Eriksson Type Ocular Albinism

Aland Islands Eye Disease

Aaland Island Eye Disease

Ocular Albinism, Type Ii
Sleeping Sickness

African Trypanosomiasis

African Sleeping Sickness

Trypanosomiasis, Human East-African

Trypanosomiasis, East African

Trypanosomiasis African

Trypanosomiasis, African

Human African Trypanosomiasis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00855 APOL3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus APOL3 MGD MGI:2444921
Rattus norvegicus APOL3 RGD RGD:1306480