2. Gene
  3. Sgpp1 - sphingosine-1-phosphate phosphatase 1 Gene

Sgpp1 - sphingosine-1-phosphate phosphatase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as SPP; SPP1; Spph1

Gene ID: 81535 | Gene type: protein coding

About Sgpp1

Summary

Enables sphingosine-1-phosphate Phosphatase activity. Involved in regulation of keratinocyte differentiation. Acts upstream of or within apoptotic signaling pathway and sphingolipid metabolic process. Located in endoplasmic reticulum and membrane. Is expressed in several structures, including adrenal gland; alimentary system; heart; liver; and urinary system. Orthologous to human SGPP1 (sphingosine-1-phosphate Phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sgpp1 Products(1)

mRNA Protein Name
NM_030750.3 NP_109675.1 sphingosine-1-phosphate phosphatase 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables sphingosine-1-phosphate phosphatase activity IDA
IDA: Inferred from direct assay
10859351 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
12235122 MGI
acts upstream of or within intrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
10859351 MGI
involved in regulation of epidermis development IMP
IMP: Inferred from mutant phenotype
23637227 MGI
involved in regulation of keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
23637227 MGI
acts upstream of or within sphinganine-1-phosphate metabolic process IDA
IDA: Inferred from direct assay
10859351 MGI
acts upstream of or within sphingolipid metabolic process IDA
IDA: Inferred from direct assay
10859351 MGI
acts upstream of or within sphingosine metabolic process IDA
IDA: Inferred from direct assay
11756451 MGI
Cellular Component GO Annotation Evidence Reference Source
NOT located in Golgi apparatus IDA
IDA: Inferred from direct assay
12235122 MGI
NOT located in actin cytoskeleton IDA
IDA: Inferred from direct assay
12235122 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
12235122 MGI
located in membrane IDA
IDA: Inferred from direct assay
10859351 MGI
NOT located in mitochondrion IDA
IDA: Inferred from direct assay
12235122 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sphingosine-1-phosphate phosphatase 1

SPPase1

sphingosine-1-phosphatase 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12810 SGPP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sgpp1 NCBI NCBI:81537