Abat - 4-aminobutyrate aminotransferase Gene

Also Known as Gabat; beta-AlaAT

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81632

Summary

Enables 4-aminobutyrate transaminase activity. Involved in several processes, including gamma-aminobutyric acid biosynthetic process; positive regulation of inhibitory postsynaptic potential; and regulation of secretion. Located in mitochondrial matrix and neuron projection. Used to study several diseases, including Huntington's disease; epilepsy (multiple); heroin dependence; ischemia; and mental depression. Biomarker of Parkinsonism. Human ortholog(s) of this gene implicated in Alzheimer's disease; GABA aminotransferase deficiency; and Huntington's disease. Orthologous to human ABAT (4-aminobutyrate aminotransferase). [provided by Alliance of Genome Resources, Apr 2022]

Abat Products (1)

mRNA Protein Name
NM_031003.2 NP_112265.1 4-aminobutyrate aminotransferase, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 4-aminobutyrate:2-oxoglutarate transaminase activity IDA
IDA: Inferred from direct assay
10447691 RGD
Biological Process GO Annotation Evidence References Source
involved in cerebellum development IEP
IEP: Inferred from expression pattern
7182074 RGD
involved in copulation IMP
IMP: Inferred from mutant phenotype
8117236 RGD
involved in exploration behavior IMP
IMP: Inferred from mutant phenotype
8788866 RGD
involved in gamma-aminobutyric acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
19540876 RGD
involved in locomotory behavior IMP
IMP: Inferred from mutant phenotype
7945972 RGD
involved in negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
8336820 RGD
involved in negative regulation of dopamine secretion IMP
IMP: Inferred from mutant phenotype
590329 RGD
involved in negative regulation of gamma-aminobutyric acid secretion IMP
IMP: Inferred from mutant phenotype
7722510 RGD
involved in positive regulation of aspartate secretion IMP
IMP: Inferred from mutant phenotype
2342602 RGD
involved in positive regulation of dopamine metabolic process IMP
IMP: Inferred from mutant phenotype
11239920 RGD
involved in positive regulation of heat generation IMP
IMP: Inferred from mutant phenotype
20878340 RGD
involved in positive regulation of inhibitory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
11495935 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
20695849 RGD
involved in positive regulation of prolactin secretion IMP
IMP: Inferred from mutant phenotype
4043235 RGD
involved in positive regulation of uterine smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
12742000 RGD
involved in response to cocaine IMP
IMP: Inferred from mutant phenotype
12373739 RGD
involved in response to ethanol IDA
IDA: Inferred from direct assay
7710740 RGD
involved in response to hypoxia IMP
IMP: Inferred from mutant phenotype
10727784 RGD
involved in response to iron ion IDA
IDA: Inferred from direct assay
9719948 RGD
involved in response to nicotine IMP
IMP: Inferred from mutant phenotype
10025686 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
7931216 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
3132542 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

4-aminobutyrate aminotransferase, mitochondrial

  • (S)-3-amino-2-methylpropionate transaminase

  • GABA aminotransferase

  • GABA transaminase

  • GABA-AT

  • GABA-T

  • L-AIBAT

  • beta-AlaAT I

  • gamma-amino-N-butyrate transaminase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00036 ABAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18027 Abat Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24500 Abat Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abat NCBI NCBI:18