PPP1R14C - protein phosphatase 1 regulatory inhibitor subunit 14C Gene

Also Known as KEPI; NY-BR-81; CPI17-like

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81706

About PPP1R14C

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:150,143,044-150,250,392 (from NCBI)

This gene has 1 transcript (splice variant), 113 orthologues and 3 paralogues. Biased expression in thyroid (RPKM 22.2), heart (RPKM 17.2) and 9 other tissues.

Summary

The degree of protein phosphorylation is regulated by a balance of protein kinase and Phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing Phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010]

PPP1R14C Products (1)

mRNA Protein Name
NM_030949.3 NP_112211.1 protein phosphatase 1 regulatory subunit 14C

PPP1R14C Protein Structure

PP1_inhibitor

PP1_inhibitor: PKC-activated protein phosphatase-1 inhibitor (51 - 162)

  • 0
  • 100
  • 165 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1 regulatory subunit 14C

  • PKC-potentiated PP1 inhibitory protein

Related Diseases

Diseases Alias
Ophthalmomyiasis

  • Ocular Myiasis

  • Ophthalmic Myiasis

  • Myiasis Oestruosa
Thyroid Dyshormonogenesis 4

  • Deiodinase Deficiency

  • TDH4

  • Iodotyrosine Dehalogenase Deficiency

  • Thyroid Hormonogenesis, Genetic Defect In, 4

  • Hypothyroidism, Congenital, Due To Dyshormonogenesis, 4

  • Genetic Defect In Thyroid Hormonogenesis 4

  • Chdh4

  • Congenital Hypothyroidism Due To Dyshormonogenesis Type 4

  • Genetic Defect In Thyroid Hormonogenesis Type 4
Familial Thyroid Dyshormonogenesis

  • Thyroid Dyshormonogenesis

  • Familial Dyshormonogenetic Goiter
Amyotrophic Lateral Sclerosis 9

  • Amyotrophic Lateral Sclerosis Type 9

  • ALS9

  • Sclerosis, Lateral, Amyotrophic, Type Type 9
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10985 PPP1R14C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PPP1R14C VGNC VGNC:76261
Mus musculus PPP1R14C MGD MGI:1923392
Rattus norvegicus PPP1R14C RGD RGD:620538
Felis catus PPP1R14C VGNC VGNC:102488
Bos taurus PPP1R14C VGNC VGNC:33227
Others PPP1R14C NCBI