PPP1R14C - protein phosphatase 1 regulatory inhibitor subunit 14C Gene

Homo sapiens

Also known as KEPI; NY-BR-81; CPI17-like

Gene ID: 81706 | Gene type: protein coding

About PPP1R14C

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:150,143,044-150,250,392 (from NCBI)

This gene has 1 transcript (splice variant), 113 orthologues and 3 paralogues. Biased expression in thyroid (RPKM 22.2), heart (RPKM 17.2) and 9 other tissues.

Summary

The degree of protein phosphorylation is regulated by a balance of protein kinase and Phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing Phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010]

PPP1R14C Products(1)

mRNA	Protein	Name
NM_030949.3	NP_112211.1	protein phosphatase 1 regulatory subunit 14C

PPP1R14C Protein Structure

PP1_inhibitor

0
100
165 a.a.

Protein Preferred Names

Protein Names

protein phosphatase 1 regulatory subunit 14C

PKC-potentiated PP1 inhibitory protein

Related Diseases

Diseases

Alias

Ophthalmomyiasis

Ocular Myiasis	Ophthalmic Myiasis
Myiasis Oestruosa

Thyroid Dyshormonogenesis 4

Deiodinase Deficiency	TDH4
Iodotyrosine Dehalogenase Deficiency	Thyroid Hormonogenesis, Genetic Defect In, 4
Hypothyroidism, Congenital, Due To Dyshormonogenesis, 4	Genetic Defect In Thyroid Hormonogenesis 4
Chdh4	Congenital Hypothyroidism Due To Dyshormonogenesis Type 4
Genetic Defect In Thyroid Hormonogenesis Type 4

Familial Thyroid Dyshormonogenesis

Thyroid Dyshormonogenesis

Familial Dyshormonogenetic Goiter

Amyotrophic Lateral Sclerosis 9

Amyotrophic Lateral Sclerosis Type 9	ALS9
Sclerosis, Lateral, Amyotrophic, Type Type 9

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10985	PPP1R14C Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PPP1R14C	VGNC	VGNC:76261
Mus musculus	PPP1R14C	MGD	MGI:1923392
Rattus norvegicus	PPP1R14C	RGD	RGD:620538
Felis catus	PPP1R14C	VGNC	VGNC:102488
Bos taurus	PPP1R14C	VGNC	VGNC:33227

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