Msh2 - mutS homolog 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81709

Summary

Predicted to enable several functions, including ATP hydrolysis activity; DNA binding activity; and protein C-terminus binding activity. Predicted to contribute to several functions, including DNA binding activity; MutLalpha complex binding activity; and adenyl ribonucleotide binding activity. Involved in several processes, including response to amino acid; response to xenobiotic stimulus; and spermatogenesis. Located in nucleus. Biomarker of colitis and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome (multiple); gastrointestinal system Cancer (multiple); lung Cancer (multiple); mismatch repair Cancer syndrome; and transitional cell carcinoma. Orthologous to human MSH2 (mutS homolog 2). [provided by Alliance of Genome Resources, Apr 2022]

Msh2 Products (1)

mRNA Protein Name
NM_031058.2 NP_112320.2 DNA mismatch repair protein Msh2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in response to amino acid IEP
IEP: Inferred from expression pattern
11026496 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18095365 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11056294 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
9034308 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA mismatch repair protein Msh2

  • mismatch repair protein

  • mutS protein homolog 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08709 MSH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18622 Msh2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25108 Msh2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Msh2 NCBI NCBI:4436