2. Gene
  3. Ggcx - gamma-glutamyl carboxylase Gene

Ggcx - gamma-glutamyl carboxylase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 81716 | Gene type: protein coding

About Ggcx

Summary

Enables gamma-glutamyl carboxylase activity and vitamin binding activity. Involved in several processes, including lung growth; peptidyl-glutamic acid carboxylation; and response to vitamin. Located in intracellular membrane-bounded organelle. Biomarker of urolithiasis. Human ortholog(s) of this gene implicated in combined deficiency of vitamin K-dependent clotting factors 1. Orthologous to human GGCX (gamma-glutamyl carboxylase). [provided by Alliance of Genome Resources, Apr 2022]

Ggcx Products(1)

mRNA Protein Name
NM_031756.1 NP_113944.1 vitamin K-dependent gamma-carboxylase
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables gamma-glutamyl carboxylase activity IDA
IDA: Inferred from direct assay
12754193 RGD
enables vitamin binding IDA
IDA: Inferred from direct assay
12754193 RGD
Biological Process GO Annotation Evidence Reference Source
involved in lung growth IEP
IEP: Inferred from expression pattern
2717270 RGD
involved in peptidyl-glutamic acid carboxylation IDA
IDA: Inferred from direct assay
12617985 RGD
involved in response to Thyroglobulin triiodothyronine IEP
IEP: Inferred from expression pattern
2717270 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
2717270 RGD
involved in response to manganese ion IEP
IEP: Inferred from expression pattern
7409196 RGD
involved in response to oxygen levels IEP
IEP: Inferred from expression pattern
3699166 RGD
involved in response to parathyroid hormone IEP
IEP: Inferred from expression pattern
6688809 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
3840747 RGD
involved in response to vitamin K IEP
IEP: Inferred from expression pattern
8702425 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vitamin K-dependent gamma-carboxylase

peptidyl-glutamate 4-carboxylase

vitamin K gamma glutamyl carboxylase

vitamin K-dependent gamma-glutamyl carboxylase

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05398 GGCX Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ggcx NCBI NCBI:2677