Mvk - mevalonate kinase Gene

Also Known as MK; Lrbp

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81727

Summary

Enables several functions, including ATP binding activity; magnesium ion binding activity; and mevalonate kinase activity. Involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway and negative regulation of translation. Located in cytosol and peroxisome. Human ortholog(s) of this gene implicated in lipid metabolism disorder; mevalonic aciduria; and porokeratosis. Orthologous to human MVK (mevalonate kinase). [provided by Alliance of Genome Resources, Apr 2022]

Mvk Products (2)

mRNA Protein Name
NM_001393702.1 NP_001380631.1 mevalonate kinase isoform 2
NM_031063.2 NP_112325.1 mevalonate kinase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
11877411 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
11877411 RGD
enables mRNA binding IDA
IDA: Inferred from direct assay
16263716 RGD
enables magnesium ion binding IDA
IDA: Inferred from direct assay
11877411 RGD
enables mevalonate kinase activity IDA
IDA: Inferred from direct assay
197206 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
20167237 RGD
enables sequence-specific mRNA binding IDA
IDA: Inferred from direct assay
14749336 RGD
Biological Process GO Annotation Evidence References Source
involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway IDA
IDA: Inferred from direct assay
197206 RGD
involved in isoprenoid biosynthetic process IDA
IDA: Inferred from direct assay
7904598 RGD
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
16263716 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14730012 RGD
located in peroxisome IDA
IDA: Inferred from direct assay
1312092 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mevalonate kinase

  • LHR mRNA binding protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08857 MVK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18739 Mvk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25226 Mvk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mvk NCBI NCBI:4598