Stxbp2 - syntaxin binding protein 2 Gene

Also Known as Munc18b

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81804

Summary

Enables syntaxin-1 binding activity and syntaxin-3 binding activity. Involved in positive regulation of mast cell degranulation and response to acidic pH. Located in apical plasma membrane; cytoplasm; and lamellipodium. Part of protein-containing complex. Colocalizes with secretory granule. Human ortholog(s) of this gene implicated in familial hemophagocytic lymphohistiocytosis 5. Orthologous to human STXBP2 (syntaxin binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Stxbp2 Products (1)

mRNA Protein Name
NM_031126.1 NP_112388.1 syntaxin-binding protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17442889 RGD
enables syntaxin binding IPI
IPI: Inferred from physical interaction
7768895 RGD
enables syntaxin-1 binding IPI
IPI: Inferred from physical interaction
7768895 RGD
enables syntaxin-3 binding IPI
IPI: Inferred from physical interaction
7768895 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
23487749 RGD
involved in regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
12482918 RGD
involved in response to acidic pH IEP
IEP: Inferred from expression pattern
15240346 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
22694344 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
12482918 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
17442889 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
17408745 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

syntaxin-binding protein 2

  • munc18-2

  • protein unc-18 homolog 2

  • protein unc-18 homolog B

  • syntaxin binding protein Munc18-2

  • unc-18 homolog 2

  • unc-18 homolog B

  • unc-18B

  • unc18-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13990 STXBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stxbp2 NCBI NCBI:6813