Stxbp2 - syntaxin binding protein 2 Gene

Rattus norvegicus

Also known as Munc18b

Gene ID: 81804 | Gene type: protein coding

About Stxbp2

Summary

Enables syntaxin-1 binding activity and syntaxin-3 binding activity. Involved in positive regulation of mast cell degranulation and response to acidic pH. Located in apical plasma membrane; cytoplasm; and lamellipodium. Part of protein-containing complex. Colocalizes with secretory granule. Human ortholog(s) of this gene implicated in familial hemophagocytic lymphohistiocytosis 5. Orthologous to human STXBP2 (syntaxin binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Stxbp2 Products(1)

mRNA	Protein	Name
NM_031126.1	NP_112388.1	syntaxin-binding protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17442889	RGD
enables syntaxin binding	IPI IPI: Inferred from physical interaction	7768895	RGD
enables syntaxin-1 binding	IPI IPI: Inferred from physical interaction	7768895	RGD
enables syntaxin-3 binding	IPI IPI: Inferred from physical interaction	7768895	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	23487749	RGD
involved in regulation of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	12482918	RGD
involved in response to acidic pH	IEP IEP: Inferred from expression pattern	15240346	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	22694344	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	12482918	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	17442889	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	17408745	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

syntaxin-binding protein 2

munc18-2	protein unc-18 homolog 2
protein unc-18 homolog B	syntaxin binding protein Munc18-2
unc-18 homolog 2	unc-18 homolog B
unc-18B	unc18-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13990	STXBP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stxbp2	NCBI	NCBI:6813

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