SLC25A28 - solute carrier family 25 member 28 Gene

Also Known as MFRN2; MRS4L; MRS3/4; NPD016

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81894

About SLC25A28

Cytogenetic location: 10q24.2 Genomic coordinates (GRCh38): 10:99,610,522-99,659,286 (from NCBI)

This gene has 10 transcripts (splice variants), 265 orthologues and 49 paralogues. Ubiquitous expression in bone marrow (RPKM 11.6), testis (RPKM 11.1) and 25 other tissues.

Summary

Predicted to enable ferrous iron transmembrane transporter activity. Predicted to be involved in iron import into the mitochondrion. Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

SLC25A28 Products (1)

mRNA Protein Name
NM_031212.4 NP_112489.3 mitoferrin-2

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
11297739 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC25A28 Protein Structure

Mito_carr

Mito_carr: Mitochondrial carrier protein (72 - 161)

Mito_carr

Mito_carr: Mitochondrial carrier protein (170 - 254)

Mito_carr

Mito_carr: Mitochondrial carrier protein (260 - 356)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
Protein Preferred Names Protein Names

mitoferrin-2

  • hMRS3/4

Related Diseases

Diseases Alias
Anemia, Sideroblastic, 1

  • Xlsa

  • X-Linked Sideroblastic Anemia

  • Hypochromic Anemia

  • Anh1

  • Hereditary Iron-Loading Anemia

  • Anemia, Sideroblastic, X-Linked

  • Anemia, Hereditary Sideroblastic

  • Erythroid 5-Aminolevulinate Synthase Deficiency

  • Hereditary Sideroblastic Anemia

  • SIDBA1

  • Anemia, Hypochromic

  • Sideroblastic Anemia 1

  • Anemia Hypochromic

  • X Chromosome-Linked Sideroblastic Anemia

  • Sideroblastic Anaemia 1

  • X-Linked Sideroblastic Anaemia

  • Anemia Hereditary Sideroblastic

  • Anemia Sex-Linked Hypochromic Sideroblastic

  • Congenital Sideroblastic Anemia

  • Sideroblastic Anemia X-Linked

  • Anemia, Sex-Linked Hypochromic Sideroblastic

  • Congenital Sideroblastic Anaemia

  • X-Linked Pyridoxine-Responsive Sideroblastic Anemia

  • Anemia Congenital Sideroblastic

  • Anemia, Sideroblastic, Type 1

  • Sex-Linked Hypochromic Sideroblastic Anaemia

  • Autosomal Recessive Sideroblastic Anaemia

  • Familial Sex Linked Hypochromic Anaemia
Protoporphyria, Erythropoietic, 1

  • Erythropoietic Protoporphyria

  • Epp

  • Ferrochelatase Deficiency

  • Protoporphyria, Erythropoietic

  • Erythrohepatic Protoporphyria

  • Heme Synthetase Deficiency

  • Autosomal Erythropoietic Protoporphyria

  • EPP1

  • Protoporphyria

  • Protoporphyria Erythropoietic
Combined Oxidative Phosphorylation Deficiency 3

  • Fatal Mitochondrial Disease Due To Combined Oxidative Phosphorylation Defect Type 3

  • COXPD3

  • Encephalomyopathy, Respiratory Failure, And Lactic Acidosis

  • Concentric Cardiomyopathy, Hypotonia, And Lactic Acidosis

  • Fatal Mitochondrial Disease Due To Coxpd3

  • Concentric Cardiomyopathy Hypotonia And Lactic Acidosis

  • Encephalomyopathy Respiratory Failure And Lactic Acidosis

  • Encephalomyopathy With Respiratory Failure And Lactic Acidosis

  • Combined Oxidative Phosphorylation Deficiency, Type 3
Acute Porphyria

  • Porphyrias, Hepatic

  • Hepatic Porphyria

  • Porphyria Hepatic

  • Acute Intermittent Porphyria
Hemochromatosis, Type 1

  • Hemochromatosis

  • Hemochromatosis Type 1

  • Hereditary Hemochromatosis

  • Hh

  • HFE1

  • Hfe Hemochromatosis, Modifier Of

  • Symptomatic Form Of Classic Hemochromatosis

  • Symptomatic Form Of Hemochromatosis Type 1

  • Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

  • Haemochromatosis

  • Iron Storage Disorder

  • Bronze Diabetes

  • Hereditary Haemochromatosis

  • Hlah

  • Hfe

  • Hemochromatosis, Hereditary

  • Diabetes Bronze

  • Classic Hemochromatosis

  • Hfe-Associated Hereditary Hemochromatosis

  • Hemochromatosis Classic

  • Bronzed Cirrhosis

  • Familial Hemochromatosis

  • Genetic Hemochromatosis

  • Hc

  • Pigmentary Cirrhosis

  • Primary Hemochromatosis

  • Troisier-Hanot-Chauffard Syndrome

  • Von Recklenhausen-Applebaum Disease

  • Hemochromatosis 1

  • Primary Hereditary Hemochromatosis

  • Bronze Cirrhosis
Sideroblastic Anemia

  • Anemia Sideroblastic

  • Anemia, Sideroblastic

  • Anemia, Hypochromic With Iron Loading
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome

  • Fowler Syndrome

  • Encephaloclastic Proliferative Vasculopathy

  • Hydrocephaly/Hydranencephaly Due To Cerebral Vasculopathy

  • PVHH

  • Epv

  • Cerebral Proliferative Glomeruloid Vasculopathy

  • Hydranencephaly, Fowler Type

  • Proliferative Vasculopathy And Hydranencephaly/Hydrocephaly

  • Fowler'S Syndrome

  • Fowler Christmas Chapple Syndrome

  • Fowler Vasculopathy

  • Polycystic Ovaries Urethral Sphincter Dysfunction

  • Voiding Dysfunction And Polycystic Ovaries

  • Fowler Vasculopaty

  • Hydranencephaly Fowler Type

  • Pgv

  • Polycystic Ovaries-Urethral Sphincter Dysfunction Syndrome
Deficiency Anemia

  • Anemia

  • Deficiency Anemias

  • Anaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13109 SLC25A28 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20230 Slc25a28 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26737 Slc25a28 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SLC25A28 RGD RGD:1584155
Bos taurus SLC25A28 VGNC VGNC:34754
Macaca mulatta SLC25A28 VGNC VGNC:77563
Mus musculus SLC25A28 MGD MGI:2180509
Others SLC25A28 NCBI