Sh3gl3 - SH3 domain containing GRB2 like 3, endophilin A3 Gene

Also Known as SH3P13; Sh3d2c1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81921

Summary

Enables protein C-terminus binding activity. Involved in negative regulation of clathrin-dependent endocytosis and positive regulation of neuron differentiation. Located in acrosomal vesicle; early endosome; and presynapse. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and postsynaptic endosome. Orthologous to human SH3GL3 (SH3 domain containing GRB2 like 3, endophilin A3). [provided by Alliance of Genome Resources, Apr 2022]

Sh3gl3 Products (4)

mRNA Protein Name
NM_001414376.1 NP_001401305.1 endophilin-A3 isoform 1
NM_031238.3 NP_112517.1 endophilin-A3 isoform 2
NM_001414376.1 NP_001401305.1 endophilin-A3 isoform 1
NM_031238.3 NP_112517.1 endophilin-A3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9238017 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of clathrin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
15066995 RGD
involved in positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
15066995 RGD
involved in regulation of clathrin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
15066995 RGD
Cellular Component GO Annotation Evidence References Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
15225413 RGD
located in early endosome IDA
IDA: Inferred from direct assay
17088211 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17088211 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17088211 RGD
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
17088211 RGD
is active in postsynaptic density, intracellular component IMP
IMP: Inferred from mutant phenotype
17088211 RGD
is active in postsynaptic endosome IDA
IDA: Inferred from direct assay
17088211 RGD
is active in postsynaptic endosome IMP
IMP: Inferred from mutant phenotype
17088211 RGD
located in presynapse IDA
IDA: Inferred from direct assay
15066995 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endophilin-A3

  • SH3 domain protein 2 C1

  • SH3 domain protein 2C

  • SH3 domain-containing GRB2-like 3

  • SH3 domain-containing GRB2-like protein 3

  • SH3-domain GRB2-like 3

  • endophilin-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12838 SH3GL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21932 Sh3gl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sh3gl3 NCBI NCBI:6457