Sh3gl3 - SH3 domain containing GRB2 like 3, endophilin A3 Gene

Rattus norvegicus

Also known as SH3P13; Sh3d2c1

Gene ID: 81921 | Gene type: protein coding

About Sh3gl3

Summary

Enables protein C-terminus binding activity. Involved in negative regulation of clathrin-dependent endocytosis and positive regulation of neuron differentiation. Located in acrosomal vesicle; early endosome; and presynapse. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and postsynaptic endosome. Orthologous to human SH3GL3 (SH3 domain containing GRB2 like 3, endophilin A3). [provided by Alliance of Genome Resources, Apr 2022]

Sh3gl3 Products(4)

mRNA	Protein	Name
NM_001414376.1	NP_001401305.1	endophilin-A3 isoform 1
NM_031238.3	NP_112517.1	endophilin-A3 isoform 2
NM_001414376.1	NP_001401305.1	endophilin-A3 isoform 1
NM_031238.3	NP_112517.1	endophilin-A3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9238017	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of clathrin-dependent endocytosis	IMP IMP: Inferred from mutant phenotype	15066995	RGD
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	15066995	RGD
involved in regulation of clathrin-dependent endocytosis	IMP IMP: Inferred from mutant phenotype	15066995	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	15225413	RGD
located in early endosome	IDA IDA: Inferred from direct assay	17088211	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17088211	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17088211	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	17088211	RGD
is active in postsynaptic density, intracellular component	IMP IMP: Inferred from mutant phenotype	17088211	RGD
is active in postsynaptic endosome	IDA IDA: Inferred from direct assay	17088211	RGD
is active in postsynaptic endosome	IMP IMP: Inferred from mutant phenotype	17088211	RGD
located in presynapse	IDA IDA: Inferred from direct assay	15066995	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

endophilin-A3

SH3 domain protein 2 C1	SH3 domain protein 2C
SH3 domain-containing GRB2-like 3	SH3 domain-containing GRB2-like protein 3
SH3-domain GRB2-like 3	endophilin-3

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12838	SH3GL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21932	Sh3gl3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sh3gl3	NCBI	NCBI:6457

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